Solution-blow spinning halloysite nanotube loaded chitosan-polyethylene oxide fibrous membrane as hemostatic dressings

IF 5.3 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2024-10-21 DOI:10.1016/j.clay.2024.107597

Jinmiao Chen , Yuxi Mo , Xiangyan Zhang , Shaohua Zhang , Aihua Cui , Xueqin Wang , Jiwei Li

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引用次数: 0

Abstract

In this study, chitosan/polyethylene oxide fibrous membranes (CS/PEO) with varying halloysite nanotubes (HNTs) contents were prepared by solution-blow spinning. The HNTs-CS/PEO membranes with a 12 wt% HNTs content exhibited excellent hydrophilicity, air permeability, and flexibility. The in vitro hemostasis time of the 12 % HNTs-CS/PEO was 217 s, and it was observed to form a stable thrombus. Moreover, the antibacterial efficacy of 12 % HNTs-CS/PEO against Escherichia coli and Staphylococcus aureus was 90.05 % and 69.86 %, respectively. Furthermore, the in vitro cytotoxicity study demonstrated the nontoxic nature of the 12 % HNTs-CS/PEO. The solution-blow spinning HNTs-CS/PEO fibrous membrane can potentially prevent the risk of distal thrombosis caused by separating individual HNTs and offer the advantages of a simple preparation and application process. This study presents a novel first-aid hemostatic dressing and offers a novel approach to loading inorganic nanoparticles onto fibers.

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溶液-吹塑-纺丝埃洛石纳米管负载壳聚糖-聚氧化乙烯纤维膜作为止血敷料

本研究通过溶液-吹塑纺丝法制备了不同哈洛石纳米管（HNTs）含量的壳聚糖/聚氧化乙烯纤维膜（CS/PEO）。HNTs 含量为 12 wt% 的 HNTs-CS/PEO 膜具有出色的亲水性、透气性和柔韧性。12% HNTs-CS/PEO 的体外止血时间为 217 秒，并能形成稳定的血栓。此外，12 % HNTs-CS/PEO 对大肠杆菌和金黄色葡萄球菌的抗菌效力分别为 90.05 % 和 69.86 %。此外，体外细胞毒性研究也证明了 12% HNTs-CS/PEO 的无毒性。溶液-吹塑纺丝 HNTs-CS/PEO 纤维膜有可能避免因分离单个 HNTs 而导致远端血栓形成的风险，并具有制备和应用过程简单的优点。本研究提出了一种新型急救止血敷料，并提供了一种将无机纳米粒子装载到纤维上的新方法。

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...