Retrospective evaluation of pediatric anaphylaxis cases according to WAO and NIAID/FAAN/EAACI criteria: A single center experience

IF 3.9 2区医学 Q2 ALLERGY

World Allergy Organization Journal Pub Date : 2024-10-24 DOI:10.1016/j.waojou.2024.100982

Funda Aytekin Güvenir MD , Gökhan Yörüsün MD , Ragıp Dere MD , Ahmet Selmanoğlu MD , Zeynep Şengül Emeksiz MD , Emine Dibek Mısırlıoğlu MD

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引用次数: 0

Abstract

Background

Anaphylaxis is an emergency that must be correctly recognized and treated by every health care professional. With the update of the World Allergy Organization (WAO) criteria in 2020, differences between the European Academy of Allergy and Immunology (EAACI)/The National Institute of Allergy and Infectious Diseases (NIAID) and the Food Allergy and Anaphylaxis Network (FAAN) and WAO criteria have come to the fore.

Objective

The aim of our study is to compare the effectiveness of these 2 criteria in diagnosing anaphylaxis in pediatric patients.

Methods

Patients aged 0–18 years who applied to Ankara Bilkent City Hospital Pediatric Immunology and Allergy Clinic between September 1, 2020 and September 1, 2023 due to systemic allergic reaction and were diagnosed with anaphylaxis were evaluated retrospectively. The clinical findings of the patients were re-evaluated accordingto WAO 2020 and NIAID/FAAN/EAACI criteria.

Results

Included in the study were 492 patients who met the inclusion criteria. Median age was 3.8 years (IQR: 0.9–11.4). The majority of patients were male (59.6%). There were 466 patients (94.1%) diagnosed with anaphylaxis according to both NIAID/FAAN/EAACI and WAO criteria. Three patients (0.6%) with isolated laryngeal involvement and 23 (4.7%) patients with isolated respiratory findings (bronchospasm) were diagnosed only according to WAO Criterion 2, for a total of 26 patients (5.3%).

Conclusion

Although the majority of patients were diagnosed with both criteria, 5.3% were diagnosed only according to the WAO criteria. After contact with a suspected or known allergen, the presence of isolated respiratory or laryngeal findings without skin findings should be a warning before anaphylaxis progresses to more serious stages.

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根据 WAO 和 NIAID/FAAN/EAACI 标准对儿科过敏性休克病例进行回顾性评估：单中心经验

背景过敏性休克是一种急症，每位医护人员都必须正确认识和处理。随着世界过敏组织（WAO）标准在2020年的更新，欧洲过敏与免疫学学会（EAACI）/美国国家过敏与传染病研究所（NIAID）和食物过敏与过敏性休克网络（FAAN）与WAO标准之间的差异凸显出来。方法回顾性评估 2020 年 9 月 1 日至 2023 年 9 月 1 日期间因全身过敏反应前往安卡拉比尔肯特市医院儿科免疫和过敏门诊就诊并被诊断为过敏性休克的 0-18 岁患者。根据 WAO 2020 和 NIAID/FAAN/EAACI 标准重新评估了患者的临床结果。中位年龄为 3.8 岁（IQR：0.9-11.4）。大多数患者为男性（59.6%）。有 466 名患者（94.1%）根据 NIAID/FAAN/EAACI 和 WAO 标准被诊断为过敏性休克。有 3 名患者（0.6%）仅根据 WAO 标准 2 诊断出喉部受累，23 名患者（4.7%）仅根据 WAO 标准 2 诊断出呼吸道症状（支气管痉挛），共计 26 名患者（5.3%）。接触疑似或已知过敏原后，在过敏性休克发展到更严重的阶段之前，出现孤立的呼吸道或喉部症状而无皮肤症状应是一个警告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Allergy Organization Journal Immunology and Microbiology-Immunology

CiteScore

9.10

自引率

5.90%

发文量

审稿时长

9 weeks

期刊介绍： The official pubication of the World Allergy Organization, the World Allergy Organization Journal (WAOjournal) publishes original mechanistic, translational, and clinical research on the topics of allergy, asthma, anaphylaxis, and clincial immunology, as well as reviews, guidelines, and position papers that contribute to the improvement of patient care. WAOjournal publishes research on the growth of allergy prevalence within the scope of single countries, country comparisons, and practical global issues and regulations, or threats to the allergy specialty. The Journal invites the submissions of all authors interested in publishing on current global problems in allergy, asthma, anaphylaxis, and immunology. Of particular interest are the immunological consequences of climate change and the subsequent systematic transformations in food habits and their consequences for the allergy/immunology discipline.