Étude capacité théranostique 2023–2024 – modélisation sur la base de la RIV-PSMA. Radiothérapie interne vectorisée (RIV), une approche théranostique à laquelle le patient doit avoir accès. Partie I : consolidation nationale

Abstract

The French Society of Nuclear Medicine (SFMN) launched the “theranostic capacity study” among establishments with nuclear medicine services (CHU, CLCC, CHG, ESPIC, Liberal Centers) to promote rapid adoption and easier access to this therapeutic innovation, either by optimizing the number of patients per service, or by considering the opening of activities in areas not covered. The SFMN intends above all to raise awareness among the establishments participating in the study about the implementation of the RIV activity, but it also wishes to enlighten national, regional and local authorities on the level of preparation of nuclear medicine services, their challenges and the difficulties they encounter. To carry out this study, the SFMN commissioned the Madis Phileo firm, which added the technical expertise of Esprimed. This study was carried out with the financial support of the company AdAcAp after validation by the Ile-de-France Regional Health Agency. The SFMN conducted this study in complete independence both in terms of the design of the study and its execution without any further intervention on the part of AdAcAp. It should be noted that in the context of this study, we talk a lot about IVR with Lu-177 PSMA, considering that it is this therapeutic modality which is likely, in the short term, to significantly increase the flow of patients. As much as possible, however, we used a global reading grid, integrating into our analyzes the other RIV treatments currently practiced in France (lutetium in neuroendocrine tumors, iodine 131, etc.), and trying, as best as possible to integrate clinical research activities which are likely to mobilize therapeutic niches. This report is made up of 2 distincts parts : Part I: National Consolidation and Part II: In-Depth Analysis.These two parts are based on the evaluation grids relating to each nuclear medicine service, anonymized and collated in an Excel file to bring together all the data collected and calculated scores in a single document. The recruitment of the 79 services was done entirely on the basis of a voluntary approach. The data collected therefore results from the cooperation of the participants to document the study and make it as relevant as possible. The restitution to all participating services of the individual nominative reports reinforced the relevance of their conclusions without giving rise to notable modifications or amendments. After checking the participating services and cross-checking the data, we are led to conclude that the study is representative of the reality of theranostic practice in France at the date of writing of this report.