Exploring the role of polysaccharides from macroalgae in shaping gut microbiome and promoting anti-obesity outcomes

IF 11 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids Pub Date : 2024-10-18 DOI:10.1016/j.foodhyd.2024.110758

Mehdi Amiri Goushki , Zahra Kharat , Gustavo Waltzer Fehrenbach , Emma J. Murphy , Declan Devine , Noel Gately , Evert Fuemayor

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引用次数: 0

Abstract

Obesity rates have risen significantly globally, yet effective and safe drug treatments remain elusive. As researchers explore alternative solutions to address this growing epidemic, macroalgae have gained attention due to their unique polysaccharides. Recent studies have highlighted the complex interactions between dietary polysaccharides and gut flora, suggesting that these carbohydrates can profoundly influence the microbial community structure and function. By focusing on the mechanisms through which these polysaccharides influence metabolic processes, this paper explores how they contribute to anti-obesity effects, such as reducing inflammation, enhancing satiety, and improving lipid metabolism. The review synthesizes findings from both in vivo and in vitro studies to present a comprehensive overview of how macroalgal polysaccharides facilitate the growth of beneficial gut bacteria, which in turn produce metabolites like short-chain fatty acids (SCFAs). These metabolites play crucial roles in energy homeostasis, immune modulation, and overall host health. However, to fully understand how these elements contribute to maintaining gut balance and overall health, more research through animal studies and human clinical trials is needed. Through this review, we aim to provide insights that could lead to more targeted and effective use of macroalgae as a functional food component in obesity management and prevention strategies.

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探索大型藻类多糖在塑造肠道微生物组和促进抗肥胖效果方面的作用

肥胖症的发病率在全球范围内大幅上升，但有效、安全的药物治疗方法却仍然难以找到。随着研究人员探索其他解决方案来应对这一日益严重的流行病，大型藻类因其独特的多糖而备受关注。最近的研究强调了膳食多糖与肠道菌群之间复杂的相互作用，表明这些碳水化合物能深刻影响微生物群落的结构和功能。通过重点研究这些多糖影响新陈代谢过程的机制，本文探讨了它们如何促进抗肥胖作用，如减少炎症、增强饱腹感和改善脂质代谢。综述综合了体内和体外研究的结果，全面概述了巨藻多糖如何促进有益肠道细菌的生长，进而产生短链脂肪酸（SCFA）等代谢物。这些代谢物在能量平衡、免疫调节和整体宿主健康方面发挥着至关重要的作用。然而，要充分了解这些元素如何有助于维持肠道平衡和整体健康，还需要通过动物实验和人体临床试验开展更多的研究。通过这篇综述，我们旨在提供一些见解，以便在肥胖管理和预防策略中更有针对性、更有效地利用大型藻类作为功能性食品成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Hydrocolloids 工程技术-食品科技

CiteScore

19.90

自引率

14.00%

发文量

871

审稿时长

37 days

期刊介绍： Food Hydrocolloids publishes original and innovative research focused on the characterization, functional properties, and applications of hydrocolloid materials used in food products. These hydrocolloids, defined as polysaccharides and proteins of commercial importance, are added to control aspects such as texture, stability, rheology, and sensory properties. The research's primary emphasis should be on the hydrocolloids themselves, with thorough descriptions of their source, nature, and physicochemical characteristics. Manuscripts are expected to clearly outline specific aims and objectives, include a fundamental discussion of research findings at the molecular level, and address the significance of the results. Studies on hydrocolloids in complex formulations should concentrate on their overall properties and mechanisms of action, while simple formulation development studies may not be considered for publication. The main areas of interest are: -Chemical and physicochemical characterisation Thermal properties including glass transitions and conformational changes- Rheological properties including viscosity, viscoelastic properties and gelation behaviour- The influence on organoleptic properties- Interfacial properties including stabilisation of dispersions, emulsions and foams- Film forming properties with application to edible films and active packaging- Encapsulation and controlled release of active compounds- The influence on health including their role as dietary fibre- Manipulation of hydrocolloid structure and functionality through chemical, biochemical and physical processes- New hydrocolloids and hydrocolloid sources of commercial potential. The Journal also publishes Review articles that provide an overview of the latest developments in topics of specific interest to researchers in this field of activity.