Advanced-designed Ru(II) complexes containing phosphinite ligands derived from chiral amino alcohols: Electrochemical behavior, DFT calculations, and biological activity

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2024-10-21 DOI:10.1016/j.jorganchem.2024.123410

Nermin Meriç , Uğur Işık , Anuar Dauletbakov , Darya Zolotareva , Alexey Zazybin , Mehmet Şerif Sever , Veysi Okumuş , Nil Ertekin Binbay , Veysel Binbay , Cezmi Kayan , Remziye Güzel , Murat Aydemir

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Abstract

We report two phosphinite ligands derived from chiral amino alcohols, and their complexes with ruthenium(II). These compounds were characterized by spectroscopic methods. Then, antimicrobial, antioxidant, and DNA binding activities of the chiral Ru(II)-phosphinite complexes were tested. Complex (1R)-2-{benzyl[(1S)-1-(naphthalen-1-yl)ethyl]amino}-1-phenylethyl diphenylphos- phinito[dichloro(η⁶-p-cymene)ruthenium(II)], 7 showed both the highest radical scavenging activity (90.93 ± 0.98 %) and the highest metal chelating activity (65.45 ± 1.46 %) at 200.0 mg l^-1 concentration. In addition, all of complexes had different rates of binding activity to calf thymus DNA (CT-DNA). Moreover, extensive theoretical and experimental investigations were conducted to gain a more profound understanding of the chemical descriptors and the diverse electronic transitions taking place within the ruthenium complexes, as well as their electrochemical characteristics.

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含有源自手性氨基醇的膦配体的高级设计 Ru(II) 复合物：电化学行为、DFT 计算和生物活性

我们报告了两种来自手性氨基醇的膦配体及其与钌（II）的配合物。这些化合物通过光谱方法进行了表征。然后，测试了手性 Ru(II)-phosphinite 复合物的抗菌、抗氧化和 DNA 结合活性。(1R)-2-{苄基[(1S)-1-(萘-1-基)乙基]氨基}-1-苯乙基二苯基磷[二氯(η6-对伞花烃)钌(II)]络合物 7 在 200.0 mg l-1 浓度下表现出最高的自由基清除活性（90.93 ± 0.98 %）和最高的金属螯合活性（65.45 ± 1.46 %）。此外，所有复合物与小牛胸腺 DNA（CT-DNA）的结合率也各不相同。此外，研究人员还进行了广泛的理论和实验研究，以更深入地了解钌配合物的化学描述和发生的各种电子转变，以及它们的电化学特性。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.