Cluster Headache Decreases Life Expectancy: A Longitudinal Assessment During 40 Years in a Headache Clinic Cohort

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Acta Neurologica Scandinavica Pub Date : 2024-10-18 DOI:10.1155/2024/3313195

Jorge Madera, Julio Pascual, Sara Pérez-Pereda, Pedro Muñoz, Vicente González-Quintanilla

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Abstract

Background: Cluster headache (CH) is one of the most disabling primary headaches. Nowadays, it is unknown if it has an impact on reducing life expectancy.

Methods: We calculated years of potential life lost (YPLL) in deceased individuals from a CH registry of a third-level hospital, using as cutoff the estimated life expectancy for our general population according to their sex and year of death. Furthermore, a descriptive and comparative analysis of the main causes of death, risk factors, and toxic habits was carried out.

Results: There were 25 deaths among the 152 individuals included. Twenty-one (84%) died earlier than expected with a mean of 9.14 YPLL (p = 0.001). Cancer was the most common cause of death in CH patients (64% of deaths vs. 28.5% expected in general population, p ≤ 0.001). Eighty percent and 45% of our deceased patients were smokers and 60% and 45% regular alcohol consumers at the diagnosis of CH and at death, respectively. The percentage of smokers at diagnosis was significantly higher than that in the reference population (80% vs. 33.2%, p < 0.001). There was a significantly higher frequency of arterial hypertension (76% vs. 19.82%, p < 0.001) and diabetes mellitus (40% vs. 7.8%, p < 0.001) at death in CH individuals compared to general population.

Conclusions: CH implies a loss of almost one decade of life expectancy by an increase in cancer deaths. Tobacco and alcohol consumption seem to be the main underlying causes. These results call for an action plan for a better management of CH patients since their diagnosis.

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丛集性头痛会缩短预期寿命：头痛门诊队列 40 年间的纵向评估

背景：丛集性头痛（CH）是致残率最高的原发性头痛之一。目前，尚不清楚丛集性头痛是否会影响预期寿命的缩短：我们从一家三级医院的头痛登记册中计算了死者的潜在寿命损失年数（YPLL），并根据死者的性别和死亡年份，以普通人群的预期寿命估计值为临界值。此外，还对主要死因、风险因素和中毒习惯进行了描述性比较分析：结果：152 人中有 25 人死亡。21人（84%）的死亡时间早于预期，平均死亡时间为9.14 YPLL（P = 0.001）。癌症是CH患者最常见的死因（占死亡人数的64%，而普通人群的预期比例为28.5%，P≤0.001）。在确诊为慢性阻塞性肺病和死亡时，分别有80%和45%的死亡患者吸烟，60%和45%的死亡患者经常饮酒。确诊时吸烟者的比例明显高于参照人群（80% vs. 33.2%，p <0.001）。与普通人群相比，CH患者死亡时患动脉高血压（76%对19.82%，p <0.001）和糖尿病（40%对7.8%，p <0.001）的频率明显更高：结论：慢性阻塞性肺病导致癌症死亡人数增加，从而使预期寿命缩短近十年。烟草和酒精消费似乎是主要的根本原因。这些结果要求制定一项行动计划，以便更好地管理确诊为慢性阻塞性肺病的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neurologica Scandinavica 医学-临床神经学

CiteScore

6.70

自引率

2.90%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.