Language, Motor Ability and Related Deficits in Children at Familial Risk of Schizophrenia or Bipolar Disorder.

IF 5.3 1区 医学 Q1 PSYCHIATRY
Marta Schiavon, Birgitte K Burton, Nicoline Hemager, Aja N Greve, Katrine S Spang, Ditte Ellersgaard, Kerstin Jessica Plessen, Jens Richardt M Jepsen, Anne A E Thorup, Thomas Werge, Merete Nordentoft, Ron Nudel
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Abstract

Background: It is known that impairments in linguistic ability and motor function tend to co-occur in children, and that children from families with parental mental illness such as schizophrenia tend to perform poorly in both domains, but the exact nature of these links has not yet been fully elucidated.

Design: In this study, we leveraged the first wave of the Danish High Risk and Resilience Study (VIA 7), which includes both genetic data and measures covering multiple developmental domains. The VIA 7 cohort comprises 522 7-year-old children born to parents with schizophrenia (N = 202), bipolar disorder (N = 120) or neither (N = 200). We investigated the relationships between linguistic ability and motor function using correlation and regression analyses, focusing on developmental coordination disorder (DCD) and specific language impairment (SLI) and their potential associations with the three risk groups.

Results: We found significant correlations between most measures of language and motor function and significant associations of DCD and SLI with language and movement measures, respectively, the largest effect being that of DCD on receptive language, with a significant interaction effect: DCD was associated with poorer performance in children from schizophrenia families compared to bipolar disorder and control families. Both disorders showed higher prevalence among children with familial high risk of mental illness. We did not find significant evidence of genetic overlap between DCD and SLI.

Conclusions: Our results suggest strong links between the domains of motor function and linguistic ability. Children of parents with schizophrenia are at high risk of comorbid language and movement disorders.

有精神分裂症或躁郁症家族风险的儿童的语言、运动能力及相关缺陷。
背景:众所周知,儿童的语言能力和运动功能障碍往往同时存在,而来自父母患有精神疾病(如精神分裂症)家庭的儿童往往在这两个领域表现不佳,但这些联系的确切性质尚未完全阐明:在这项研究中,我们利用了丹麦高风险和复原力研究(VIA 7)的第一波数据,其中包括遗传数据和涵盖多个发育领域的测量数据。VIA 7队列包括522名7岁儿童,他们的父母分别患有精神分裂症(202人)、双相情感障碍(120人)或两者均无(200人)。我们使用相关分析和回归分析研究了语言能力与运动功能之间的关系,重点研究了发育协调障碍(DCD)和特殊语言障碍(SLI)及其与三个风险组的潜在关联:我们发现,大多数语言和运动功能的测量结果之间存在明显的相关性,而发育协调障碍和特殊语言障碍分别与语言和运动测量结果存在明显的关联,其中发育协调障碍对接受性语言的影响最大,并存在明显的交互影响:与双相情感障碍和对照组家庭相比,精神分裂症家庭的儿童在 DCD 方面表现较差。这两种疾病在家族性高风险精神疾病儿童中的发病率都较高。我们没有发现 DCD 和 SLI 遗传重叠的重要证据:我们的研究结果表明,运动功能和语言能力之间存在密切联系。父母患有精神分裂症的儿童合并语言和运动障碍的风险很高。
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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
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