Calculated estimation of the metabolic clearance rate of insulin measured by glucose clamp examination in out-patient clinical practice.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2024-09-23 eCollection Date: 2024-10-01 DOI:10.1007/s13340-024-00752-3

Noboru Kurinami, Seigo Sugiyama, Akira Yoshida, Kunio Hieshima, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Katsunori Jinnouchi, Hideaki Jinnouchi

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Abstract

Purpose: A subpopulation of Japanese patients with type 2 diabetes mellitus (T2DM) who have elevated insulin clearance (IC) exists. We tested our hypothesis that it is possible to estimate IC using common and simple test results collected in routine clinical practice.

Methods: We recruited patients with newly diagnosed, treatment-naïve T2DM and measured the metabolic clearance rate of insulin (MCRI) determined by a hyperinsulinemic-euglycemic clamp examination. Multivariable regression analysis was performed with body mass index (BMI), serum uric acid (UA), and fasting plasma insulin (F-IRI) which were independently associated with IC increase in our previous reports as explanatory variables to calculate a prediction equation for MCRI.

Results: We enrolled 101 patients in this study. Because MCRI is not normally distributed, we calculated the logarithmically transformed estimated Log₁₀MCRI as a prediction formula for IC. Multivariable regression analysis showed that Log₁₀BMI (β = - 0.3257, P < 0.001), UA (β = - 0.1834, P = 0.0081), and Log₁₀F-IRI (β = - 0.4367, P < 0.001) were significant independent factors for Log₁₀MCRI. The regression equation was as follows: estimated Log₁₀MCRI = - 0.5421 × Log₁₀BMI - 0.0167 × UA - 0.1792 × Log₁₀F-IRI + 3.8251 (r = 0.7677, R ² = 0.5894, P < 0.001).

Conclusion: IC can easily be predicted using BMI, UA, and F-IRI which are common and simple test results collected in routine clinical practice.

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在门诊临床实践中，通过葡萄糖钳夹检查对胰岛素代谢清除率进行计算估算。

目的：日本 2 型糖尿病（T2DM）患者中存在胰岛素清除率（IC）升高的亚群。我们测试了我们的假设，即使用常规临床实践中收集到的常见和简单的测试结果可以估算出胰岛素清除率：我们招募了新诊断的、未经治疗的 T2DM 患者，并通过高胰岛素血糖钳夹检查测定了胰岛素代谢清除率（MCRI）。以体重指数（BMI）、血清尿酸（UA）和空腹血浆胰岛素（F-IRI）为解释变量进行多变量回归分析，计算出 MCRI 的预测方程：本研究共招募了 101 名患者。由于 MCRI 并非正态分布，我们计算了对数变换后的估计 Log10MCRI，作为 IC 的预测公式。多变量回归分析表明，Log10BMI（β = - 0.3257，P P = 0.0081）和 Log10F-IRI （β = - 0.4367，P 10MCRI。回归方程如下：估计的 Log10MCRI = - 0.5421 × Log10BMI - 0.0167 × UA - 0.1792 × Log10F-IRI + 3.8251（r = 0.7677，R 2 = 0.5894，P 结论：根据 BMI 预测的 IC 值可以很容易地推测出 BMI 值：使用 BMI、UA 和 F-IRI 可以很容易地预测 IC，这些都是在常规临床实践中收集到的常见且简单的检测结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.