A bioactive multifunctional dressing with simultaneous visible monitoring of pH values and H₂O₂ concentrations for promoting diabetic wound healing.

IF 12.2 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Materials Horizons Pub Date : 2024-10-29 DOI:10.1039/d4mh01142b

Jimin Huang, Jinzhou Huang, XinXin Zhang, Qinyi Xie, Yi Zheng, Chaoqin Shu, Zhe Shi, Xiao Wang, Jiajie Chen, Bing Ma, Chengtie Wu, Yufang Zhu

{"title":"A bioactive multifunctional dressing with simultaneous visible monitoring of pH values and H2O2 concentrations for promoting diabetic wound healing.","authors":"Jimin Huang, Jinzhou Huang, XinXin Zhang, Qinyi Xie, Yi Zheng, Chaoqin Shu, Zhe Shi, Xiao Wang, Jiajie Chen, Bing Ma, Chengtie Wu, Yufang Zhu","doi":"10.1039/d4mh01142b","DOIUrl":null,"url":null,"abstract":"Wound healing in diabetes is a complex physiological process with risks of ulceration and amputation. Real-time monitoring and treatment of diabetic wounds is an effective prevention of further deterioration. Herein, a multifunctional dressing is developed by encapsulating europium-containing bioactive glass (EuBG) and MoO3-x in a biocompatible sodium alginate (SA) dressing (MoO3-x-EuBG-SA), aiming to simultaneously monitor the wound pH value and hydrogen peroxide (H2O2) concentration, establish an anti-inflammatory microenvironment, and promote wound healing. The pH-responsive fluorescence quenching effect of EuBG contributes to visible monitoring of pH values, and MoO3-x enables high responsiveness and accurate colorimetric indication of H2O2 variability to understand the dynamic wound status. Then, these fluorescent and colorimetric changes can be captured using a smartphone and transformed into signals for wound pH values and H2O2 concentrations, enabling rapid and convenient real-time assessment of wound dynamics. Furthermore, the MoO3-x-EuBG-SA dressing can reduce inflammation and promote the proliferation, differentiation, and migration of fibroblasts and endothelial cells in vitro with the help of the released bioactive Si, Ca, and Mo ions. Notably, the MoO3-x-EuBG-SA dressing exhibits excellent abilities to monitor a wound microenvironment and immune regulation and promote diabetic wound healing in vivo. Overall, the multifunctional dressing has great potential for managing diabetic wounds and promoting wound healing.","PeriodicalId":87,"journal":{"name":"Materials Horizons","volume":" ","pages":""},"PeriodicalIF":12.2000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Horizons","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1039/d4mh01142b","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound healing in diabetes is a complex physiological process with risks of ulceration and amputation. Real-time monitoring and treatment of diabetic wounds is an effective prevention of further deterioration. Herein, a multifunctional dressing is developed by encapsulating europium-containing bioactive glass (EuBG) and MoO_3-x in a biocompatible sodium alginate (SA) dressing (MoO_3-x-EuBG-SA), aiming to simultaneously monitor the wound pH value and hydrogen peroxide (H₂O₂) concentration, establish an anti-inflammatory microenvironment, and promote wound healing. The pH-responsive fluorescence quenching effect of EuBG contributes to visible monitoring of pH values, and MoO_3-x enables high responsiveness and accurate colorimetric indication of H₂O₂ variability to understand the dynamic wound status. Then, these fluorescent and colorimetric changes can be captured using a smartphone and transformed into signals for wound pH values and H₂O₂ concentrations, enabling rapid and convenient real-time assessment of wound dynamics. Furthermore, the MoO_3-x-EuBG-SA dressing can reduce inflammation and promote the proliferation, differentiation, and migration of fibroblasts and endothelial cells in vitro with the help of the released bioactive Si, Ca, and Mo ions. Notably, the MoO_3-x-EuBG-SA dressing exhibits excellent abilities to monitor a wound microenvironment and immune regulation and promote diabetic wound healing in vivo. Overall, the multifunctional dressing has great potential for managing diabetic wounds and promoting wound healing.

查看原文本刊更多论文

一种生物活性多功能敷料，可同时监测 pH 值和 H2O2 浓度，促进糖尿病伤口愈合。

糖尿病患者的伤口愈合是一个复杂的生理过程，存在溃疡和截肢的风险。对糖尿病伤口进行实时监测和治疗可有效防止伤口进一步恶化。本文通过将含铕生物活性玻璃（EuBG）和MoO3-x封装在生物相容性海藻酸钠（SA）敷料（MoO3-x-EuBG-SA）中，开发了一种多功能敷料，旨在同时监测伤口pH值和过氧化氢（H2O2）浓度，建立抗炎微环境，促进伤口愈合。EuBG 的 pH 响应荧光淬灭效应有助于对 pH 值进行可视化监测，而 MoO3-x 则可实现对 H2O2 变化的高响应性和精确比色指示，从而了解伤口的动态状况。然后，可以使用智能手机捕捉这些荧光和比色变化，并将其转化为伤口 pH 值和 H2O2 浓度的信号，从而实现快速、便捷的伤口动态实时评估。此外，MoO3-x-EuBG-SA 敷料还能在体外利用释放的生物活性 Si、Ca 和 Mo 离子减轻炎症，促进成纤维细胞和内皮细胞的增殖、分化和迁移。值得注意的是，MoO3-x-EuBG-SA 敷料在监测伤口微环境和免疫调节以及促进体内糖尿病伤口愈合方面表现出卓越的能力。总之，这种多功能敷料在管理糖尿病伤口和促进伤口愈合方面具有巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

18.90

自引率

2.30%

发文量

306

审稿时长

1.3 months

期刊介绍： Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.