TrkB signalling regulates dopamine circuits and motor function through metabolic pathways

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-10-28 DOI:10.1038/s42255-024-01154-0

引用次数: 0

Abstract

A common feature of neurodegenerative diseases is that select neuronal types are particularly sensitive to disease pathology at early stages. Altered TrkB signalling in the neuronal type most affected by Huntington’s disease increased expression of the enzyme GSTO2, leading to dopaminergic dysfunction, impaired energy metabolism, progressive degeneration and hyperkinetic symptoms.

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TrkB 信号通过代谢途径调节多巴胺回路和运动功能

神经退行性疾病的一个共同特点是，某些神经元类型在早期阶段对疾病病理特别敏感。受亨廷顿氏病影响最严重的神经元类型的 TrkB 信号改变会增加 GSTO2 酶的表达，从而导致多巴胺能功能障碍、能量代谢受损、进行性变性和过度运动症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.