Synthesis and anti-inflammatory activity of N-substituted 4-aryl-2-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-4-oxobut-2-enamides

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-10-26 DOI:10.1007/s11172-024-4389-1

I. A. Gorbunova, E. A. Okoneshnikova, R. R. Makhmudov, V. M. Shadrin, P. S. Silaichev, S. A. Shipilovskikh, D. A. Shipilovskikh

引用次数: 0

Abstract

Synthesis of N-substituted 4-aryl-2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxobut-2-enamides by the reaction of the substituted 2-[(5-aryl-2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles with primary amines was developed. Anti-inflammatory activity and acute toxicity of the synthesized compounds were examined. It was found that the synthesized compounds possess pronounced anti-inflammatory activity and low toxicity. According to the classification of toxicity of drugs, the synthesized amides belong to toxicity class V of practically nontoxic substances.

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N-取代的 4-芳基-2-[(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)氨基]-4-氧代丁-2-烯酰胺的合成和抗炎活性

通过取代的 2-[(5-芳基-2-氧代呋喃-3(2H)-亚基)氨基]-4,5,6,7-四氢苯并[b]噻吩-3-甲腈与伯胺的反应，合成了 N-取代的 4-芳基-2-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基氨基)-4-氧代丁基-2-烯酰胺。研究了合成化合物的抗炎活性和急性毒性。结果发现，合成的化合物具有明显的抗炎活性和较低的毒性。根据药物毒性的分类，合成的酰胺属于毒性第 V 类几乎无毒的物质。

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.