An efficient and environmental friendly synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione in aqueous hydrotropic medium

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2024-10-25 DOI:10.1007/s12039-024-02310-5

Nilam S Dhane, Aboli C Sapkal, Nilam P Dhumal, Dhananjay N Gaikwad, Santosh B Kamble, Kishor V Gaikwad

引用次数: 0

Abstract

This study reports a hydrotropic activity for synthesizing 1H-pyrazolo[1,2-b]phthalazine-5,10-dione through one pot four component aldehyde condensation, malononitrile, phthalic anhydride, and hydrazine hydrate. The simple and green hydrotropic synthetic approach offers numerous advantages such as non-toxic, inexpensive, mild reaction conditions, avoidance of harmful solvents, shorter reaction time, an excellent yield of products, simple workup, Chromatography-free, and eco-friendly. ¹H-NMR confirmed all the synthesized compounds.

Graphical abstract

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在水介质中高效、环保地合成 1H-吡唑并[1,2-b]酞嗪-5,10-二酮

本研究报告了一种通过一锅四组分醛缩合、丙二腈、邻苯二甲酸酐和水合肼合成 1H-吡唑并[1,2-b]酞嗪-5,10-二酮的水合活性。这种简单而绿色的水托合成方法具有诸多优点，如无毒、成本低廉、反应条件温和、避免使用有害溶剂、反应时间短、产品收率高、操作简单、无需色谱分析以及环保等。1H-NMR 证实了所有合成的化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.