Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI:10.3762/bjoc.20.218

Battini Veeraiah, Kishore Ramineni, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Chada Raji Reddy, Frédéric Justaud, René Grée

引用次数: 0

Abstract

In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.

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新型 N-芳基苯并[h]喹唑啉-2-胺的合成和细胞毒性研究。

在本文中，我们报告了一种新型 N-芳基苯并[h]喹唑啉-2-胺的简短高效合成方法。我们制备了一个由 19 个具有代表性的实例组成的重点文库，并对这些实例进行了细胞毒性测试，结果显示，其中几个分子对 8 种癌症细胞株具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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