Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia
{"title":"Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer's disease.","authors":"Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia","doi":"10.1038/s43587-024-00732-x","DOIUrl":null,"url":null,"abstract":"<p><p>The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer's disease (AD)<sup>1</sup> and is commonly used as an outcome in clinical trials<sup>2</sup>. It relies on information provided by the patient and an informant<sup>3</sup>. The CDR-SB should reflect only the patient's disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer's disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient's child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer's disease trials and research.</p>","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s43587-024-00732-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer's disease (AD)1 and is commonly used as an outcome in clinical trials2. It relies on information provided by the patient and an informant3. The CDR-SB should reflect only the patient's disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer's disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient's child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer's disease trials and research.