Informant characteristics influence Clinical Dementia Rating Sum of Boxes scores-based staging of Alzheimer’s disease

IF 17 Q1 CELL BIOLOGY
Juan-Camilo Vargas-Gonzalez, Antonella Santuccione Chadha, Laura Castro-Aldrete, Maria Teresa Ferretti, Maria Carmela Tartaglia
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引用次数: 0

Abstract

The Clinical Dementia Rating Sum of Boxes (CDR-SB) is a staging scale for Alzheimer’s disease (AD)1 and is commonly used as an outcome in clinical trials2. It relies on information provided by the patient and an informant3. The CDR-SB should reflect only the patient’s disease severity. However, we explored whether informant characteristics were associated with CDR-SB scores because that association might introduce bias in Alzheimer’s disease research. We found that the CDR-SB was 0.20 higher when informants were female, 0.39 higher when the informant was a patient’s child and 0.18 lower if the relationship was other than spouse or children. Regarding the frequency of contact, CDR-SB scores were 0.38 higher when contact was at least once a week, 0.65 higher when daily and 0.57 higher when living with the patient. Our analysis results suggest that informant characteristics can modify the CDR-SB scores and might introduce bias into Alzheimer’s disease trials and research. Vargas-Gonzalez et al. report an influence of informant characteristics on the Clinical Dementia Rating Sum of Boxes (CDR-SB), a scale designed to stage patients with Alzheimer’s disease, which is commonly used as an outcome for clinical trials.
信息提供者的特征会影响基于临床痴呆分级的阿尔茨海默病分期。
临床痴呆评定量表(CDR-SB)是阿尔茨海默病(AD)的分期量表1 ,通常用作临床试验的结果2。它依赖于患者和信息提供者提供的信息3。CDR-SB 应仅反映患者的疾病严重程度。然而,我们探讨了信息提供者的特征是否与 CDR-SB 分数相关,因为这种关联可能会在阿尔茨海默病研究中引入偏差。我们发现,如果信息提供者是女性,则 CDR-SB 高 0.20;如果信息提供者是患者的子女,则 CDR-SB 高 0.39;如果非配偶或子女关系,则 CDR-SB 低 0.18。在接触频率方面,每周至少接触一次的 CDR-SB 得分高 0.38,每天接触的高 0.65,与患者同住的高 0.57。我们的分析结果表明,信息提供者的特征会改变 CDR-SB 的得分,并可能给阿尔茨海默病的试验和研究带来偏差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.70
自引率
0.00%
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0
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