Physiological and tumor-associated angiogenesis: Key factors and therapy targeting VEGF/VEGFR pathway

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2024-10-22 DOI:10.1016/j.biopha.2024.117585

Patryk Lorenc , Agata Sikorska , Sara Molenda , Natalia Guzniczak , Hanna Dams-Kozlowska , Anna Florczak

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引用次数: 0

Abstract

Cancer remains one of the leading causes of death worldwide and poses a significant challenge to effective treatment due to its complexity. Angiogenesis, the formation of new blood vessels, is one of the cancer hallmarks and is a critical process in tumor growth and metastasis. The pivotal role of angiogenesis in cancer development has made antiangiogenic treatment a promising strategy for cancer therapy. To develop an effective therapy, it is essential to understand the basics of the physiological and tumor angiogenesis process. This review presents the primary factors related to physiological and tumor angiogenesis and the mechanisms of angiogenesis in tumors. We summarize potential molecular targets for cancer treatment by focusing on the vasculature, with the VEGF/VEGFR pathway being one of the most important and well-studied. Additionally, we present the advantages and limitations of currently used clinical protocols for cancer treatment targeting the VEGF/VEGFR pathway.

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生理性和肿瘤相关性血管生成：关键因素和针对血管内皮生长因子/血管内皮生长因子受体通路的疗法。

癌症仍然是导致全球死亡的主要原因之一，由于其复杂性，对有效治疗构成了巨大挑战。血管生成（新血管的形成）是癌症的特征之一，也是肿瘤生长和转移的关键过程。血管生成在癌症发展中的关键作用使抗血管生成治疗成为一种前景广阔的癌症治疗策略。要开发有效的疗法，了解生理和肿瘤血管生成过程的基本原理至关重要。本综述介绍了与生理性血管生成和肿瘤血管生成相关的主要因素以及肿瘤血管生成的机制。我们以血管为重点，总结了治疗癌症的潜在分子靶点，其中血管内皮生长因子/血管内皮生长因子受体途径是最重要和研究最深入的靶点之一。此外，我们还介绍了目前针对血管内皮生长因子/血管内皮生长因子受体通路的癌症治疗临床方案的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.