Evaluation of salivary melatonin and MMP-9 levels in periodontal diseases

IF 2.2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2024-10-20 DOI:10.1016/j.archoralbio.2024.106116

Ali Batuhan Bayırlı , Ceyda Gürhan , Ercan Saruhan

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引用次数: 0

Abstract

Objective

The aim of this study was to evaluate salivary matrix metalloproteinase-9 (MMP-9) and melatonin levels in individuals with periodontal health, gingivitis, and periodontitis.

Design

A total of 170 participants were enrolled in this study. They included 57 periodontally healthy individuals, 58 gingivitis patients, and 55 periodontitis patients. Saliva samples were collected by passive drool technique. The levels of MMP-9 and melatonin in saliva were measured biochemically using the ELISA method.

Results

Salivary MMP-9 levels in the periodontitis group were significantly higher than those in the gingivitis and periodontally healthy groups, while salivary melatonin levels were significantly lower (p<0.001). A positive correlation was observed between clinical periodontal parameters and salivary MMP-9 levels, while salivary melatonin levels were negatively correlated (p<0.001). A negative correlation was also observed between salivary MMP-9 levels and salivary melatonin levels (p<0.001).

Conclusion

This study shows that the level of melatonin in saliva is associated with periodontal disease and with the level of MMP-9 in saliva, which plays a role in this disease.

查看原文本刊更多论文

评估牙周病患者唾液中的褪黑激素和 MMP-9 水平。

研究目的本研究旨在评估牙周健康、牙龈炎和牙周炎患者的唾液基质金属蛋白酶-9（MMP-9）和褪黑激素水平：设计：本研究共招募了 170 名参与者。设计：这项研究共招募了 170 名参与者，其中包括 57 名牙周健康者、58 名牙龈炎患者和 55 名牙周炎患者。采用被动流口水技术采集唾液样本。采用酶联免疫吸附法对唾液中的 MMP-9 和褪黑激素水平进行生化测定：结果：牙周炎组唾液中 MMP-9 的水平明显高于牙龈炎组和牙周健康组，而唾液中褪黑激素的水平则明显低于牙龈炎组和牙周健康组（p 结论：该研究表明，褪黑激素在牙周炎患者唾液中的水平明显高于牙龈炎组和牙周健康组：本研究表明，唾液中褪黑激素的水平与牙周病和唾液中 MMP-9 的水平有关，而 MMP-9 在牙周病中起着一定的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry