The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2024-10-23 DOI:10.1016/j.neubiorev.2024.105931

Chuoyi Liang , Sijia Wei , Yelin Ji , Jiayi Lin , Wenli Jiao , Zhiying Li , Fengxia Yan , Xi Jing

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引用次数: 0

Abstract

Depression is a debilitating mental disorder that causes a persistent feeling of sadness and loss of interest. Approximately 280 million individuals worldwide suffer from depression by 2023. Despite the heavy medical and social burden imposed by depression, pathophysiology remains incompletely understood. Emerging evidence indicates various bidirectional interplay enable communication between the gut and brain. These interplays provide a link between intestinal and central nervous system as well as feedback from cortical and sensory centers to enteric activities, which also influences physiology and behavior in depression. This review aims to overview the significant role of the enteric nervous system (ENS) in the pathophysiology of depression and gut-brain axis’s contribution to depressive disorders. Additionally, we explore the alterations in enteric glia cells (EGCs) and glial cell line-derived neurotrophic factor (GDNF) in depression and their involvement in neuronal support, intestinal homeostasis maintains and immune response activation. Modulating ENS function, EGCs and GDNF level could serve as novel strategies for future antidepressant therapy.

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肠道神经系统和 GDNF 在抑郁症中的作用：大脑与肠道之间的对话。

抑郁症是一种使人衰弱的精神障碍，会导致持续的悲伤感和兴趣丧失。到 2023 年，全球约有 2.8 亿人患有抑郁症。尽管抑郁症造成了沉重的医疗和社会负担，但人们对其病理生理学的了解仍不全面。新出现的证据表明，肠道和大脑之间存在各种双向的相互作用。这种相互作用提供了肠道和中枢神经系统之间的联系，以及大脑皮层和感觉中枢对肠道活动的反馈，这也影响了抑郁症患者的生理和行为。本综述旨在概述肠道神经系统（ENS）在抑郁症病理生理学中的重要作用以及肠脑轴对抑郁障碍的贡献。此外，我们还探讨了抑郁症患者肠胶质细胞（EGCs）和胶质细胞系源性神经营养因子（GDNF）的变化，以及它们在神经元支持、肠道稳态维持和免疫反应激活方面的参与。调节 ENS 功能、EGCs 和 GDNF 水平可作为未来抗抑郁治疗的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.