TTF-1 immunohistochemistry in primary CNS tumors: A systematic review.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropathology Pub Date : 2024-10-24 DOI:10.5414/NP301642

Sumanta Das, Sunita Ahlawat, Jayati Sarangi, Arun Kumar Panda, Priti Jain, Rakesh Kumar Gupta, Sandeep Vaishya, Rana Patir

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引用次数: 0

Abstract

Thyroid transcription factor-1 (TTF-1) is a nuclear protein primarily recognized for its role in the development and differentiation of thyroid, lung, and certain diencephalic tissues. Although well-established as an immunohistochemical marker in thyroid and lung cancers, recent studies have explored its expression and diagnostic value in primary central nervous system (CNS) tumors. This systematic review aims to consolidate current knowledge on TTF-1 immunohistochemistry in primary CNS tumors, assessing its prevalence, diagnostic utility, and clinical implications. The review encompasses various CNS tumor types, including subependymal giant cell astrocytoma, chordoid glioma, pituicytoma, ependymomas, astrocytomas, glioblastomas, medulloblastomas, and choroid plexus tumors, highlighting the potential role of TTF-1 in differentiating these neoplasms from other CNS and metastatic tumors. By synthesizing findings from multiple studies, this review underscores the diagnostic value of TTF-1 in the neuropathological evaluation of CNS tumors and suggests directions for future research to refine its clinical application.

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原发性中枢神经系统肿瘤中的 TTF-1 免疫组化：系统综述。

甲状腺转录因子-1（TTF-1）是一种核蛋白，主要在甲状腺、肺和某些间脑组织的发育和分化过程中发挥作用。虽然作为甲状腺癌和肺癌的免疫组化标志物已得到广泛认可，但最近的研究也探讨了它在原发性中枢神经系统（CNS）肿瘤中的表达和诊断价值。本系统综述旨在整合目前有关原发性中枢神经系统肿瘤中 TTF-1 免疫组化的知识，评估其患病率、诊断效用和临床意义。该综述涵盖了各种中枢神经系统肿瘤类型，包括脐下巨细胞星形细胞瘤、脊髓胶质瘤、颅底细胞瘤、上胚瘤、星形细胞瘤、胶质母细胞瘤、髓母细胞瘤和脉络丛肿瘤，强调了 TTF-1 在区分这些肿瘤与其他中枢神经系统肿瘤和转移性肿瘤方面的潜在作用。本综述综合了多项研究的结果，强调了 TTF-1 在中枢神经系统肿瘤神经病理学评估中的诊断价值，并提出了今后完善其临床应用的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropathology 医学-病理学

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.