Marian Blazes, Caitlyn Ngadisastra, Pei-Ru Li, Cecilia S Lee, Jiahn-Shing Lee, Lai-Chu See, Ken-Kuo Lin
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引用次数: 0
Abstract
Purpose: Obstructive sleep apnea (OSA) may increase the risk of age-related macular degeneration (AMD) due to repetitive oxygen deprivation or other mechanisms, though whether OSA increases the risk of AMD progression is unknown. We analyzed associations between OSA and AMD risk in the Taiwanese population.
Methods: We identified patients diagnosed with OSA between 2000 and 2018 in the Taiwan National Health Insurance Research Database and used 1:1 propensity score matching on demographics and co-morbidities to create a non-OSA cohort. We used Cox proportional hazard modeling to investigate the risk of AMD and the risk of progression from nonexudative to exudative AMD in OSA versus non-OSA patients.
Results: A total of 66,869 OSA patients were matched with 66,869 non-OSA patients. The hazard ratio (HR) of AMD in the OSA cohort was 1.36 (95% confidence interval[CI]: 1.31-1.43, p<.0001). The HR for progression from nonexudative to exudative AMD for the OSA cohort was 0.94 (95%CI: 0.77-1.14, p=0.5073).
Conclusion: OSA is associated with a higher risk of developing AMD. However, no increased risk of AMD progression is observed among people with OSA and existing non-exudative AMD.
目的：阻塞性睡眠呼吸暂停（OSA）可能会因反复缺氧或其他机制而增加老年性黄斑变性（AMD）的风险，但OSA是否会增加AMD进展的风险尚不清楚。我们分析了台湾人群中 OSA 与 AMD 风险之间的关联：我们在台湾国民健康保险研究数据库中确定了2000年至2018年期间被诊断为OSA的患者，并根据人口统计学和合并疾病采用1:1倾向得分匹配法创建了非OSA队列。我们采用Cox比例危险模型研究了OSA与非OSA患者发生AMD的风险以及从非渗出性AMD发展为渗出性AMD的风险：共有 66,869 名 OSA 患者与 66,869 名非 OSA 患者进行了配对。OSA队列中AMD的危险比（HR）为1.36（95%置信区间[CI]：1.31-1.43，P＜0.05）：结论：OSA与罹患AMD的较高风险有关。然而，在患有 OSA 和现有非渗出性 AMD 的人群中，并未观察到 AMD 进展的风险增加。
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