Insights into the Rising Threat of Carbapenem-Resistant Enterobacterales and Pseudomonas aeruginosa Epidemic Infections in Eastern Europe: A Systematic Literature Review.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

Antibiotics-Basel Pub Date : 2024-10-17 DOI:10.3390/antibiotics13100978

Michal Piotrowski, Irina Alekseeva, Urs Arnet, Emre Yücel

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引用次数: 0

Abstract

Background: Antimicrobial resistance is a major global public health challenge, particularly with the rise of carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA). This study aimed to describe the characteristics of CRE and CRPA infections in Eastern Europe, focusing on Bulgaria, Croatia, Czechia, Greece, Hungary, Poland, Romania, Serbia, Slovakia, and Slovenia.

Methods: Following MOOSE and PRISMA guidelines, a systematic literature review of articles published between 1 November 2017 and 1 November 2023 was conducted using the MEDLINE, Embase, Web of Science, CDSR, DARE, and CENTRAL databases. The search strategy used a combination of free text and subject headings to gather pertinent literature regarding the incidence and treatment patterns of CRE and CRPA infections. A total of 104 studies focusing on infections in both children and adults were included in this review.

Results: This review revealed a significant prevalence of carbapenem-resistant Gram-negative isolates and underscored the effectiveness of imipenem/relebactam and ceftazidime/avibactam (CAZ/AVI) against Klebsiella pneumoniae carbapenemase-producing Enterobacterales and of ceftolozane/tazobactam, imipenem/relebactam and ceftazidime/avibactam against non-metallo-β-lactamase-producing CRPA strains.

Conclusions: This study highlights the urgent need for comprehensive measures to combat the escalating threat of CRE and CRPA infections in Eastern European countries. At the same time, it shows the activity of the standard of care and new antimicrobials against carbapenem-resistant Gram-negative pathogens in Eastern Europe. Clinical real-world data on the treatment of carbapenem-resistant infections in Eastern Europe are needed.

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揭示东欧耐碳青霉烯类肠杆菌和铜绿假单胞菌流行性感染的上升威胁：系统性文献综述》。

背景：抗菌药耐药性是全球公共卫生面临的一大挑战，尤其是随着耐碳青霉烯类肠杆菌（CRE）和铜绿假单胞菌（CRPA）的增加。本研究旨在描述东欧 CRE 和 CRPA 感染的特点，重点关注保加利亚、克罗地亚、捷克、希腊、匈牙利、波兰、罗马尼亚、塞尔维亚、斯洛伐克和斯洛文尼亚：按照 MOOSE 和 PRISMA 指南，使用 MEDLINE、Embase、Web of Science、CDSR、DARE 和 CENTRAL 数据库对 2017 年 11 月 1 日至 2023 年 11 月 1 日期间发表的文章进行了系统性文献综述。检索策略采用自由文本和主题词相结合的方式，收集有关 CRE 和 CRPA 感染的发病率和治疗模式的相关文献。本综述共收录了 104 篇关于儿童和成人感染的研究：结果：综述显示耐碳青霉烯类革兰氏阴性菌分离株的发病率很高，并强调了亚胺培南/雷巴坦和头孢唑肟/阿维巴坦（CAZ/AVI）对产碳青霉烯酶肠杆菌肺炎克雷伯菌的有效性，以及头孢洛氮烷/他唑巴坦、亚胺培南/雷巴坦和头孢唑肟/阿维巴坦对非金属-β-内酰胺酶产CRPA菌株的有效性：本研究强调，迫切需要采取综合措施来应对东欧国家不断升级的 CRE 和 CRPA 感染威胁。同时，该研究还显示了东欧地区标准护理和新型抗菌药物对耐碳青霉烯类革兰氏阴性病原体的活性。我们需要有关东欧耐碳青霉烯菌感染治疗的临床实际数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics

CiteScore

7.30

自引率

14.60%

发文量

1547

审稿时长

11 weeks

期刊介绍： Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.