The relationship between advanced lung cancer inflammation index and high SYNTAX score in patients with non-ST-elevation myocardial infarction.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Postepy W Kardiologii Interwencyjnej Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI:10.5114/aic.2024.142239

Ali Hakan Konuş, Ahmet Özderya, Ömer Faruk Çırakoğlu, Muhammet Raşit Sayın, Murat Gökhan Yerlikaya

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引用次数: 0

Abstract

Introduction: The advanced lung cancer inflammation index (ALI) is an independent prognostic biomarker of inflammation and nutrition in various types of cancer, acute heart failure and acute coronary syndrome. The SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery) score (SXscore) is an angiographic scoring tool used to determine the extent and severity of coronary artery disease.

Aim: To investigate the relationship between ALI and coronary artery lesion complexity assessed using the SXscore in patients with non-ST-segment elevation myocardial infarction (NSTEMI).

Material and methods: Between February and November 2020, a total of 284 patients with NSTEMI were included consecutively. ALI was calculated with the formula body mass index (BMI) × serum albumin concentration/neutrophil-to-lymphocyte ratio (NLR). SXscore was calculated using the online calculator and divided into two groups - low (< 32) and high (≥ 33) - and then analyzed.

Results: Patients with a high SXscore had lower ALI (22.4 ±7.3 vs. 58.5 ±44.3, p = 0.016). In the univariable analysis, age (p = 0.046), BMI (p = 0.021), C-reactive protein (p = 0.002), peak troponin I (p = 0.009), NLR (p = 0.025), serum albumin (p = 0.003) and ALI (p < 0.001) were significantly associated with a high SXscore. ALI emerged as an independent predictor of a high SXscore in multivariable analysis (95% CI: 0.931-0.984, p = 0.002).

Conclusions: The ALI may be useful as a simple tool for predicting high SXscore in patients with NSTEMI. To our knowledge, this is the first study to examine the relationship between ALI and severity of CAD.

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非ST段抬高型心肌梗死患者的晚期肺癌炎症指数与SYNTAX高分之间的关系

简介晚期肺癌炎症指数（ALI）是各种癌症、急性心力衰竭和急性冠状动脉综合征中炎症和营养的独立预后生物标志物。SYNTAX（经皮冠状动脉介入治疗与TAXUS和心脏手术之间的协同作用）评分（SXscore）是一种血管造影评分工具，用于确定冠状动脉疾病的范围和严重程度。目的：研究非ST段抬高型心肌梗死（NSTEMI）患者中ALI与使用SXscore评估的冠状动脉病变复杂性之间的关系：2020年2月至11月期间，连续纳入了284名NSTEMI患者。ALI的计算公式为体重指数（BMI）×血清白蛋白浓度/中性粒细胞与淋巴细胞比值（NLR）。使用在线计算器计算 SX 评分，将其分为低（< 32）和高（≥ 33）两组，然后进行分析：结果：SX评分高的患者ALI较低（22.4 ±7.3 vs. 58.5 ±44.3，p = 0.016）。在单变量分析中，年龄（p = 0.046）、体重指数（p = 0.021）、C 反应蛋白（p = 0.002）、肌钙蛋白 I 峰值（p = 0.009）、NLR（p = 0.025）、血清白蛋白（p = 0.003）和 ALI（p < 0.001）与高 SX 评分显著相关。在多变量分析中，ALI成为高SX评分的独立预测因子（95% CI：0.931-0.984，p = 0.002）：ALI可作为预测NSTEMI患者高SX评分的简单工具。据我们所知，这是第一项研究ALI与CAD严重程度之间关系的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postepy W Kardiologii Interwencyjnej 医学-心血管系统

CiteScore

1.60

自引率

15.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Postępy w Kardiologii Interwencyjnej/Advances in Interventional Cardiology is indexed in: Index Copernicus, Ministry of Science and Higher Education Index (MNiSW). Advances in Interventional Cardiology is a quarterly aimed at specialists, mainly at cardiologists and cardiosurgeons. Official journal of the Association on Cardiovascular Interventions of the Polish Cardiac Society.