The Role of Macrophages in Airway Disease Focusing on Porcine Reproductive and Respiratory Syndrome Virus and the Treatment with Antioxidant Nanoparticles.

IF 3.8 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2024-10-01 DOI:10.3390/v16101563

Kyuhyung Choi

引用次数: 0

Abstract

Lung macrophage cells play a critical role in various lung diseases, and their state can change depending on the progression of the disease by inducing either an inflammatory or anti-inflammatory state. In this review, the potential therapeutic effects of treatment with antioxidant nanoparticles in air-borne diseases focusing on porcine reproductive and respiratory virus (PRRSV), considering reactive oxygen species (ROS) as one of the factors that regulate M1 and M2 macrophages in the inflammatory and anti-inflammatory states, respectively, was described. In addition, the author examines the status of protein structure research on CD163 (one of the markers of anti-inflammatory M2 macrophages) in human and veterinary lung diseases.

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巨噬细胞在气道疾病中的作用，聚焦猪繁殖与呼吸综合征病毒及纳米抗氧化剂的治疗。

肺巨噬细胞在各种肺部疾病中发挥着关键作用，其状态会随着疾病的进展而改变，诱发炎症或抗炎状态。在这篇综述中，考虑到活性氧（ROS）是分别在炎症和抗炎状态下调节 M1 和 M2 巨噬细胞的因素之一，作者以猪生殖与呼吸道病毒（PRRSV）为重点，阐述了抗氧化纳米粒子治疗空气传播疾病的潜在疗效。此外，作者还探讨了 CD163（抗炎 M2 巨噬细胞的标志物之一）在人类和兽医肺部疾病中的蛋白结构研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.