The Management of Hematopoietic Stem Cell Transplant in People with HIV.

IF 3.8 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2024-09-30 DOI:10.3390/v16101560

Jana K Dickter, Courtney Moc Willeford

引用次数: 0

Abstract

Hematopoietic stem cell transplant (HSCT) is now recognized as a standard treatment option for people with HIV (PWH) who develop high-risk hematologic malignancies. However, the involved polypharmacy can lead to complications from drug interactions and toxicities, affecting the efficacy and safety of chemotherapy and antiretroviral therapy (ART). Managing these patients requires a personalized approach, including the careful selection of ART based on previous therapies and potential interactions, alongside risk assessment for infections. This discussion will address the history of HSCT in PWH and management considerations for this group.

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艾滋病病毒感染者的造血干细胞移植管理。

造血干细胞移植（HSCT）是目前公认的治疗艾滋病病毒感染者（PWH）高危血液恶性肿瘤的标准方案。然而，其中涉及的多种药物可能会导致药物相互作用和毒性并发症，影响化疗和抗逆转录病毒疗法（ART）的疗效和安全性。管理这些患者需要采取个性化的方法，包括根据既往疗法和潜在的相互作用谨慎选择抗逆转录病毒疗法，同时进行感染风险评估。本讨论将探讨造血干细胞移植在 PWH 中的应用历史以及这类患者的管理注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.