Noninvasive Monitoring of Glycemia Level in Diabetic Patients by Wearable Advanced Biosensors.

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL
Elena V Daboss, Maria A Komkova, Vita N Nikitina, Egor A Andreev, Darya V Vokhmyanina, Arkady A Karyakin
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Abstract

We report on the possibility of noninvasive diabetes monitoring through continuous analysis of sweat. The prediction of the blood glucose level in diabetic patients is possible on the basis of their sweat glucose content due to the positive correlation discovered. The ratio between the blood glucose and sweat glucose concentrations for a certain diabetic subject is stable within weeks, excluding requirements for frequent blood probing. The glucose variations in sweat display allometric (non-linear) dependence on those in blood, allowing more precise blood glucose estimation. Selective (avoiding false-positive responses) and sensitive (sweat glucose is on average 30-50 times lower) detection is possible with biosensors based on the glucose oxidase enzyme coupled with a Prussian Blue transducer. Reliable glucose detection in just secreted sweat would allow noninvasive monitoring of the glycemia level in diabetic patients.

利用可穿戴式先进生物传感器对糖尿病患者的血糖水平进行无创监测
我们报告了通过连续分析汗液进行无创糖尿病监测的可能性。由于发现了正相关关系,因此可以根据糖尿病患者的汗液葡萄糖含量预测其血糖水平。某位糖尿病患者的血糖和汗液葡萄糖浓度之间的比率在数周内保持稳定,无需频繁抽血检测。汗液中的葡萄糖变化与血液中的葡萄糖变化呈异速(非线性)关系,从而可以更精确地估计血糖。基于葡萄糖氧化酶和普鲁士蓝传感器的生物传感器可进行选择性(避免假阳性反应)和灵敏性(汗液葡萄糖平均低 30-50 倍)检测。通过对分泌汗液中的葡萄糖进行可靠检测,可以对糖尿病患者的血糖水平进行无创监测。
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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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