Needle Tip Tracking through Photoluminescence for Minimally Invasive Surgery.

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL
Meenakshi Narayan, Mithun Bhowmick
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引用次数: 0

Abstract

Minimally invasive surgery continues to prioritize patient safety by improving imaging techniques and tumor detection methods. In this work, an all-optical alternative to the current image based techniques for in vitro minimally invasive procedures has been explored. The technique uses a highly fluorescent marker for the surgical needle to be tracked inside simulated tissues. A series of markers were explored including inorganic (Perovskite and PbS) and organic (carbon dots) nanoparticles and organic dye (Rhodamine 6G) to identify layers of different stiffnesses within a tissue. Rhodamine 6G was chosen based on its high fluorescence signal to track 3D position of a surgical needle in a tissue. The needle was tracked inside homogeneous and inhomogeneous gelatin tissues successfully. This exploratory study of tissue characterization and needle tip tracking using fluorescent markers or photoluminescence technique show potential for real-time application of robot-assisted needle insertions during in vivo procedures.

通过光致发光追踪针尖,用于微创手术。
通过改进成像技术和肿瘤检测方法,微创手术继续将患者安全放在首位。在这项工作中,我们探索了一种全光学技术来替代目前基于图像的体外微创手术技术。该技术使用一种高荧光标记,用于在模拟组织内跟踪手术针。研究人员探索了一系列标记物,包括无机(Perovskite 和 PbS)和有机(碳点)纳米粒子以及有机染料(罗丹明 6G),以识别组织内不同硬度的层。之所以选择罗丹明 6G,是因为它具有高荧光信号,可跟踪手术针在组织中的三维位置。在均质和不均质的明胶组织中都成功地追踪到了针的位置。这项利用荧光标记或光致发光技术进行组织特征描述和针尖追踪的探索性研究,显示了在体内手术中实时应用机器人辅助插针的潜力。
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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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