Effect of Helicobacter pylori Eradication on Serum Level of Valproic Acid in Children with Idiopathic Generalized Epilepsy.

IF 2 4区医学 Q2 PEDIATRICS

Children-Basel Pub Date : 2024-10-18 DOI:10.3390/children11101259

Abobakr Abdelgalil, Doaa Ismail, Ayman Eskander, Marian Girgis, Ahmed Farouk, Fajr Saeedi, Mohamed Shazly, Amera Hasnoon

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引用次数: 0

Abstract

Background/objectives: The purpose of this study was to determine the influence of H. pylori eradication on the serum level of the orally administered valproic acid (VPA) in children with idiopathic generalized epilepsy; Methods: This prospective cohort observational study included 100 children with idiopathic generalized epilepsy, recruited from a neurology clinic from May 2021 to December 2021. The patients were divided into two groups, each containing 50 children. The first group had a positive H. pylori stool antigen and H. pylori-related symptoms, while the second group had a negative antigen. H. pylori Eradication therapy was given to the positive H. pylori group. The serum level of VPA was obtained at baseline and 4 weeks after eradication therapy.

Results: Despite there being no significant difference between the H. pylori-positive and H. pylori-negative groups regarding the baseline VPA serum level (79.9 ± 13.9 and 77.9 ± 13.1 mcg/mL), respectively, the serum VPA level had significantly increased after H. pylori eradication therapy (99.4 ± 11 mcg/mL) (p value = 0.000), as opposed to the H. pylori-negative group (85.3 ± 10.9 mcg/mL) (p value = 0.142). Furthermore, there was a statistically significant association with a negative correlation between the VPA serum level after eradication and the number of epileptic attacks per month (p value = 0.033, R value = -0.301) and the dose of VPA (p value = 0.046, R value = -0.284).

Conclusions: The eradication of H. pylori resulted in a highly significant improvement in the serum level of the orally given VPA in children with idiopathic generalized epilepsy, as well as an indirect decrease in the frequency of epileptic events per month, allowing for dose reduction. Eradication therapy may have anticonvulsant properties and might indirectly aid in the management of epileptic activity. H. pylori screening for children with idiopathic generalized epilepsy can optimize serum VPA levels, potentially leading to better seizure control. To our knowledge, this is the first study in the literature to describe the effect of H. pylori eradication on the serum level of the orally administered VPA in children with idiopathic generalized epilepsy.

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根除幽门螺杆菌对特发性全身性癫痫儿童血清丙戊酸水平的影响

背景/目的：本研究的目的是确定根除幽门螺杆菌对特发性全身性癫痫患儿血清中口服丙戊酸（VPA）水平的影响；方法：这项前瞻性队列观察研究纳入了 100 名特发性全身性癫痫患儿，他们都是 2021 年 5 月至 2021 年 12 月期间从神经内科诊所招募的。患者分为两组，每组 50 人。第一组患儿的幽门螺杆菌粪便抗原呈阳性，并伴有幽门螺杆菌相关症状，而第二组患儿的抗原呈阴性。幽门螺杆菌阳性组接受根除幽门螺杆菌治疗。分别在基线和根除治疗 4 周后检测血清中的 VPA 水平：结果：尽管幽门螺杆菌阳性组和幽门螺杆菌阴性组的 VPA 血清基线水平（79.9 ± 13.9 和 77.9 ± 13.1 mcg/mL）没有明显差异，但幽门螺杆菌阴性组的 VPA 血清基线水平（79.9 ± 13.9 和 77.9 ± 13.1 mcg/mL），与幽门螺杆菌阴性组（85.3 ± 10.9 mcg/mL）（p 值 = 0.142）相比，幽门螺杆菌根除治疗后血清 VPA 水平显著增加（99.4 ± 11 mcg/mL）（p 值 = 0.000）。此外，根除幽门螺杆菌后的VPA血清水平与每月癫痫发作次数（p值=0.033，R值=-0.301）和VPA剂量（p值=0.046，R值=-0.284）之间存在统计学意义上的显著负相关：结论：根除幽门螺杆菌可显著改善特发性全身性癫痫患儿口服 VPA 的血清水平，并间接降低每月癫痫发作的频率，从而减少剂量。根除疗法可能具有抗惊厥特性，可间接帮助控制癫痫活动。对特发性全身性癫痫患儿进行幽门螺杆菌筛查可以优化血清VPA水平，从而有可能更好地控制癫痫发作。据我们所知，这是文献中第一项描述根除幽门螺杆菌对特发性全身性癫痫患儿血清中口服VPA水平影响的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.