Bacteriological Profile and Antibiotic Susceptibility of Neonatal Sepsis Cases in the Neonatal Intensive Care Unit of a Tertiary Hospital in Türkiye.

IF 2 4区医学 Q2 PEDIATRICS

Children-Basel Pub Date : 2024-09-30 DOI:10.3390/children11101208

Bayram Ali Dorum, Şefika Elmas Bozdemir, Bensu Zadeoğlu Kral, Ayten Erdoğan, Salih Çağrı Çakır

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引用次数: 0

Abstract

Objective: We aimed to determine the demographic data, mortality, and morbidity of early- and late-neonatal sepsis cases, the etiologic agents in these cases, and the antibiotic susceptibility of these agents.

Methods: This study was conducted retrospectively in a tertiary neonatal intensive care unit (NICU). The demographic, clinical, and laboratory data of newborns diagnosed with culture-proven sepsis within 24 months were evaluated.

Results: Two hundred and eleven culture data points belonging to 197 infants were evaluated. Forty percent of the infants had a history of premature birth. The most common clinical findings were respiratory distress and feeding intolerance. Coagulase-negative staphylococci (CoNS) were detected most frequently as early- and late-sepsis agents. The most common Gram-negative bacteria detected as late-sepsis agents were Klebsiella spp. and Escherichia coli (E. coli). The overall mortality rate was 10%.

Conclusions: Neonatal sepsis continues to have high mortality rates in tertiary NICUs. CoNS was the most common agent, highlighting the importance of developing and maintaining personnel training and handwashing practices. It will be important to consider the resistance rates of Klebsiella spp., the most common Gram-negative agent in late-onset sepsis (LOS) cases, to commonly used antibiotics in empirical treatments.

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土耳其一家三甲医院新生儿重症监护室新生儿败血症病例的细菌学特征和抗生素敏感性。

目的我们旨在确定早期和晚期新生儿败血症病例的人口统计学数据、死亡率和发病率、这些病例的病原体以及这些病原体对抗生素的敏感性：本研究在一家三级医院的新生儿重症监护室（NICU）中以回顾性方式进行。评估了 24 个月内经培养证实患有败血症的新生儿的人口统计学、临床和实验室数据：对 197 名婴儿的 211 个培养数据点进行了评估。40%的婴儿有早产史。最常见的临床表现是呼吸困难和喂养不耐受。凝固酶阴性葡萄球菌（CoNS）作为早期和晚期败血症病原体最常被检测到。最常见的晚期败血症革兰氏阴性菌是克雷伯氏菌属和大肠埃希氏菌（大肠杆菌）。总死亡率为 10%：结论：新生儿败血症在三级新生儿重症监护病房的死亡率仍然很高。CoNS是最常见的病原体，这凸显了开展和保持人员培训和洗手规范的重要性。克雷伯氏菌是晚发性败血症（LOS）病例中最常见的革兰氏阴性菌，考虑其对经验性治疗中常用抗生素的耐药率非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Children-Basel PEDIATRICS-

CiteScore

2.70

自引率

16.70%

发文量

1735

审稿时长

6 weeks

期刊介绍： Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.