Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review.

IF 2 4区 医学 Q2 PEDIATRICS
Maria-Myrto Dourdouna, Elizabeth-Barbara Tatsi, Vasiliki Syriopoulou, Athanasios Michos
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引用次数: 0

Abstract

Background/objectives: Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19. MIS-C has overlapping features with other pediatric inflammatory disorders including Kawasaki Disease (KD), Macrophage Activation Syndrome (MAS), Toxic Shock Syndrome and sepsis. The exact mechanisms responsible for the clinical overlap between MIS-C and these conditions remain unclear, and biomarkers that could distinguish MIS-C from its clinical mimics are lacking. This study aimed to provide an overview of how proteomic methods, like Mass Spectrometry (MS) and affinity-based proteomics, can offer a detailed understanding of pathophysiology and aid in the diagnosis and prognosis of MIS-C.

Methods: A narrative review of relevant studies published up to July 2024 was conducted.

Results: We identified 15 studies and summarized their key proteomic findings. These studies investigated the serum or plasma proteome of MIS-C patients using MS, Proximity Extension, or Aptamer-based assays. The studies associated the proteomic profile of MIS-C with laboratory and clinical parameters and/or compared it with that of other diseases including acute COVID-19, KD, MAS, pediatric rheumatic diseases, sepsis and myocarditis or pericarditis following COVID-19 mRNA immunization. Depending on the method and the control group, different proteins were increased or decreased in the MIS-C group. The limitations and challenges in MIS-C proteomic research are also discussed, and future research recommendations are provided.

Conclusions: Although proteomics appear to be a promising approach for understanding the pathogenesis and uncovering candidate biomarkers in MIS-C, proteomic studies are still needed to recognize and validate biomarkers that could accurately discriminate MIS-C from its clinical mimics.

与 COVID-19 有关的儿童多系统炎症综合征(MIS-C)的蛋白质组特征:叙述性综述。
背景/目的:儿童多系统炎症综合征(MIS-C)是 COVID-19 感染后的一种并发症。儿童多系统炎症综合征与川崎病(KD)、巨噬细胞活化综合征(MAS)、中毒性休克综合征和败血症等其他儿科炎症性疾病有重叠特征。造成 MIS-C 与这些疾病临床重叠的确切机制仍不清楚,也缺乏能将 MIS-C 与其临床模拟物区分开来的生物标志物。本研究旨在概述蛋白质组学方法(如质谱法(MS)和基于亲和力的蛋白质组学)如何详细了解病理生理学并帮助诊断 MIS-C 和预后:方法:对截至 2024 年 7 月发表的相关研究进行叙述性综述:结果:我们确定了 15 项研究,并总结了这些研究的主要蛋白质组学发现。这些研究使用 MS、Proximity Extension 或基于 Aptamer 的检测方法研究了 MIS-C 患者的血清或血浆蛋白质组。这些研究将 MIS-C 的蛋白质组特征与实验室和临床参数联系起来,并/或与其他疾病的蛋白质组特征进行比较,包括急性 COVID-19、KD、MAS、小儿风湿病、败血症以及 COVID-19 mRNA 免疫后的心肌炎或心包炎。根据不同的方法和对照组,MIS-C 组中不同的蛋白质会增加或减少。本文还讨论了MIS-C蛋白质组学研究的局限性和挑战,并提出了未来的研究建议:尽管蛋白质组学似乎是了解MIS-C发病机制和发现候选生物标志物的一种很有前景的方法,但仍需要进行蛋白质组学研究,以识别和验证能准确区分MIS-C和其临床模拟物的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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