Evaluation of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and mean platelet volume levels in pediatric keratoconus patients.

IF 0.6 Q4 OPHTHALMOLOGY

Saudi Journal of Ophthalmology Pub Date : 2024-09-20 eCollection Date: 2024-07-01 DOI:10.4103/sjopt.sjopt_170_24

Müge Toprak, Özgül Altıntaş, Özge Y Sezer, Büşra Yılmaz Tuğan

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引用次数: 0

Abstract

Purpose: To examine the level of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the pediatric patient group with keratoconus.

Methods: Patients aged 5-18 years with a diagnosis of keratoconus followed by the corneal department and children in the similar age group who were determined as controls were included in the study. Their topographies were evaluated. In both groups, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) were measured.

Results: The study group consisted of children aged 15 ± 1.4 years and the control group 13 ± 1.3 years of age. The mean central corneal thickness of the patients in the patient group was 445.64 μm, and in the control group was 532.25 μm. The NLR was 3.37 ± 1.04 in the patient group and 2.31 ± 0.82 in the control group. The PLR was significantly increased in the KC group (147.54 ± 41.36) than in the control group (118.71 ± 27.11) (P = 0.042). MPV in the patient group was 12.18 ± 2.76 and 7.00 ± 1.37 in the control group. This value was found to be statistically significant (P = 0.047) when the control group and the patient group were compared.

Conclusion: Platelet/lymphocyte ratio and mean platelet volume, which are thought to be new markers of systemic inflammation, may be new indices in keratoconus in pediatric patients.

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评估小儿角膜炎患者的中性粒细胞-淋巴细胞比率、血小板-淋巴细胞比率和平均血小板体积水平。

目的：研究中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率在角膜炎儿童患者群体中的水平：研究对象包括经角膜病科诊断为角膜炎的 5-18 岁患者，以及被确定为对照组的年龄相仿的儿童。对他们的地形图进行了评估。对两组儿童的中性粒细胞/淋巴细胞比率（NLR）、血小板/淋巴细胞比率（PLR）和平均血小板体积（MPV）进行了测量：研究组儿童的年龄为（15 ± 1.4）岁，对照组儿童的年龄为（13 ± 1.3）岁。患者组的平均角膜中心厚度为 445.64 μm，对照组为 532.25 μm。患者组的 NLR 为 3.37 ± 1.04，对照组为 2.31 ± 0.82。KC 组的 PLR（147.54 ± 41.36）明显高于对照组（118.71 ± 27.11）（P = 0.042）。患者组的 MPV 为 12.18 ± 2.76，对照组为 7.00 ± 1.37。将对照组和患者组进行比较后发现，这一数值具有统计学意义（P = 0.047）：血小板/淋巴细胞比值和平均血小板体积被认为是全身炎症的新标志，可能是儿童患者角膜炎的新指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Saudi Journal of Ophthalmology is an English language, peer-reviewed scholarly publication in the area of ophthalmology. Saudi Journal of Ophthalmology publishes original papers, clinical studies, reviews and case reports. Saudi Journal of Ophthalmology is the official publication of the Saudi Ophthalmological Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.