Full-term pregnancy despite severe hypophosphatemia caused by tumor-induced osteomalacia.

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL
Oxford Medical Case Reports Pub Date : 2024-10-26 eCollection Date: 2024-10-01 DOI:10.1093/omcr/omae125
Thien Binh Nu Truong, Anh Trong Nguyen, Luong Dai Ly
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引用次数: 0

Abstract

A woman in her 30s with a history of multiple bone fractures unexpectedly became pregnant and delivered a full-term baby through cesarean section, despite suffering from excruciating pain without any apparent cause or specific treatment. The patient was referred to our endocrine clinic following childbirth. Blood tests revealed a life-threatening low level of serum phosphate, normal 25-hydroxy vitamin D concentration, low TmP/GFR ratio, and elevated FGF23 levels. A PET/CT scan with Gallium-68 Dotatate identified an abnormal tumor in the right calcaneus. Her FGF23 level returned to normal soon after surgical removal of the tumor, which was confirmed to be chondroblastoma. Her child's cognitive and motor skills typically developed from the newborn to preschool age. He exhibited excellent long-term growth, without any signs of rickets.

肿瘤引起的骨软化症导致严重低磷血症,但仍能足月妊娠。
一名 30 多岁、有多处骨折病史的妇女意外怀孕并通过剖腹产分娩了一个足月的婴儿,尽管她忍受着剧烈的疼痛,却没有任何明显的原因或具体的治疗方法。产后,患者被转诊到我们的内分泌诊所。血液化验结果显示,患者血清磷酸盐水平偏低,25-羟基维生素 D 浓度正常,TmP/GFR 比值偏低,FGF23 水平升高,危及生命。PET/CT 扫描发现右侧小腿骨有一个异常肿瘤。手术切除肿瘤后,她的 FGF23 水平很快恢复正常,经证实为软骨母细胞瘤。她的孩子从新生儿到学龄前期的认知和运动能力都得到了很好的发展。他的长期生长状况良好,没有任何佝偻病的迹象。
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来源期刊
Oxford Medical Case Reports
Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
125
审稿时长
19 weeks
期刊介绍: Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.
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