Progress and challenges in human developmental cell atlas.

Q3 Medicine

遗传 Pub Date : 2024-10-01 DOI:10.16288/j.yczz.24-153

Yi-Chen Que, Qing-Quan Liu, Yi-Chi Xu

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引用次数: 0

Abstract

Illustrating molecular mechanisms of human embryonic development has always been one of the most significant challenges in biology. The scarcity of human embryo samples, the difficulty in dissecting embryo samples, and the complex structures of human organs are the major obstacles in studying human embryogenesis. In recent years, with the rapid advancement of single-cell technology, humans can systematically analyze the dynamic changes in differentiation at various stages of the central dogma and achieve observation and research with spatial information. This has accelerated the progress in constructing a human developmental cell atlas, ultimately allowing us to depict the cell ontology, fate trajectories, and three-dimensional dynamic changes of human development. In this review, we first introduce the single-cell technologies used to construct the atlas, then summarize the latest progress in human developmental cell atlas, followed by identifying the main problems and challenges in this field so far. Finally, we discuss how to utilize the human developmental cell atlas to address key biological and medical issues. This review provides guidance for the optimal use of single-cell omics technology in constructing and applying a human developmental cell atlas.

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人类发育细胞图谱的进展与挑战。

说明人类胚胎发育的分子机制一直是生物学领域最重大的挑战之一。人类胚胎样本稀少、胚胎样本解剖困难、人体器官结构复杂是研究人类胚胎发育的主要障碍。近年来，随着单细胞技术的突飞猛进，人类可以系统分析中枢教条各阶段分化的动态变化，实现空间信息的观察和研究。这加快了人类发育细胞图谱的构建进度，最终使我们能够描绘人类发育的细胞本体、命运轨迹和三维动态变化。在这篇综述中，我们首先介绍了用于构建图谱的单细胞技术，然后总结了人类发育细胞图谱的最新进展，接着指出了该领域迄今为止存在的主要问题和挑战。最后，我们讨论了如何利用人类发育细胞图谱解决关键的生物学和医学问题。这篇综述为在构建和应用人类发育细胞图谱过程中优化使用单细胞组学技术提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.