Clinicopathologic characterization of secretory carcinoma of salivary gland.

IF 2.5 3区医学 Q3 ONCOLOGY

World Journal of Surgical Oncology Pub Date : 2024-10-25 DOI:10.1186/s12957-024-03561-9

Fei Han, Feng Liu, Hao Wang, Yanchao Qin, Qian Lu, Xuesong Wu, Zhen Guo, Xinrong Nan

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Abstract

Background: To investigate the clinicopathologic characteristics, therapeutic methods, and prognosis of secretory carcinoma of salivary gland (SCSG).

Methods: The clinicopathologic data of 13 patients with SCSG admitted to Shanxi Cancer Hospital from January 2018 to June 2023 were retrospectively analyzed, and a literature review was performed.

Results: A total of eight males and five females aged 22-78 years old were enrolled, and they commonly presented with painless masses in the parotid or submandibular gland. They all underwent surgical treatment, accompanied by typical pathological examinations postoperatively. Fluorescence in situ hybridization (FISH) was conducted in seven cases, the results were all positive, and no gene fusion other than ETV6-NTRK3 was found. Two patients developed local relapse during follow-up, both of which were in the surgical area. By the end of the follow-up, 12 patients survived and one patient died.

Conclusions: SCSG is a rare low-grade malignancy with a good prognosis. Pathological and immunohistochemical characteristics are the key to secretory carcinoma (SC) diagnosis, and surgical excision is the major treatment means for SCSG. Whether to perform simultaneous cervical lymph node dissection and other adjuvant therapies should be determined based on the pathological stage and the presence or absence of high-risk factors.

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唾液腺分泌性癌的临床病理学特征。

背景：研究唾液腺分泌性癌（SCSG）的临床病理特征、治疗方法和预后：目的：探讨唾液腺分泌性癌（SCSG）的临床病理特点、治疗方法及预后：回顾性分析山西省肿瘤医院2018年1月至2023年6月收治的13例SCSG患者的临床病理资料，并进行文献综述：入选患者共8男5女，年龄22-78岁，常见表现为腮腺或颌下腺无痛性肿块。他们都接受了手术治疗，术后进行了典型的病理检查。对7例患者进行了荧光原位杂交（FISH），结果均为阳性，除ETV6-NTRK3外未发现其他基因融合。两名患者在随访期间出现局部复发，均发生在手术区域。随访结束时，12名患者存活，1名患者死亡：SCSG是一种罕见的低度恶性肿瘤，预后良好。病理和免疫组化特征是诊断分泌性癌（SC）的关键，手术切除是SCSG的主要治疗手段。是否同时进行宫颈淋巴结清扫术和其他辅助治疗，应根据病理分期和有无高危因素来决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.