Chorionicity and Psychomotor Development From Infancy to Childhood: The Japan Environment and Children's Study.

IF 1 4区医学 Q4 GENETICS & HEREDITY

Twin Research and Human Genetics Pub Date : 2024-10-28 DOI:10.1017/thg.2024.39

Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Satoyo Ikehara, Junji Miyazaki, Kanami Tanigawa, Takashi Kimura, Ryo Kawasaki, Hiroyasu Iso

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引用次数: 0

Abstract

Twins lag behind singletons in their early psychomotor development, but little is known about how chorionicity affects this difference. We compared early psychomotor development in singletons, monochorionic (MC) twins and dichorionic (DC) twins. Our longitudinal data from the Japan Environment and Children's Study (JECS; see Appendix) included 98,042 singletons, 577 MC twins and 1051 DC twins representing the general Japanese population. Chorionicity was evaluated by ultrasound images and complemented by postnatal pathological examinations. Five domains of psychomotor development were evaluated at 6 time points from 6 months to 3 years of age using the Ages and Stages Questionnaires (ASQ-3). The data were analyzed using linear regression models. Twins lagged behind singletons in all areas of psychomotor development during infancy. This gap decreased over time but was still noticeable at 3 years of age. More than half of this difference was attributed to twins having lower birth weight and being born earlier in gestation. MC twins showed slightly delayed development compared to DC twins, but this difference was minor compared to the overall gap between twins and singletons. Twins delay singletons in their early psychomotor development, and this delay is not specific to MC twinning.

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绒毛膜性与婴儿期至儿童期的心理运动发育：日本环境与儿童研究

双胞胎的早期精神运动发育落后于单胎，但人们对绒毛膜性如何影响这种差异知之甚少。我们比较了单胞胎、单绒毛膜双胎（MC）和双绒毛膜双胎（DC）的早期精神运动发育情况。我们从日本环境与儿童研究（Japan Environment and Children's Study，JECS；见附录）中获得的纵向数据包括 98,042 个单胎、577 个 MC 双胞胎和 1051 个 DC 双胞胎，这些数据代表了日本的总体人口。绒毛率通过超声波图像进行评估，并辅以产后病理检查。使用年龄与阶段问卷（ASQ-3）在 6 个月至 3 岁的 6 个时间点对五个精神运动发育领域进行了评估。数据采用线性回归模型进行分析。在婴儿期，双胞胎在心理运动发展的所有方面都落后于单胎。随着时间的推移，这种差距逐渐缩小，但在 3 岁时仍很明显。这一差距的一半以上归因于双胞胎出生体重较轻和出生时间较早。与单胞胎相比，双胞胎的发育略有延迟，但与双胞胎和单胞胎之间的总体差距相比，这种差异很小。双胞胎在早期精神运动发育方面比单胎落后，而这种落后并不是单胞双胎所特有的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Twin Research and Human Genetics 医学-妇产科学

CiteScore

1.50

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.