Genetic factors of equine osteochondrosis and fetlock osteochondral fragments: A scoping review - Part 2

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
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Abstract

Equine osteochondrosis and osteochondral fragments in the fetlock joint are linked to various environmental and genetic risk factors. To assess the scope of the literature linking these risk factors to the development of these osteochondral disorders, while identifying knowledge gaps and challenges to guide future research, a scoping review was performed. This article constitutes the second part of this scoping review and focuses on genetic factors, with the first part addressing environmental factors. To identify potentially relevant papers, online bibliographical databases PubMed and Web of Science were utilised, supplemented with articles listed on the OMIA website (OMIA:000750–9796). After collecting entries, removing duplicates, screening titles, abstracts, and full-text documents for eligibility, and manually searching reference lists of the remaining articles, a total of 212 studies were identified for this scoping review. First, a brief overview of the etiopathogenesis of equine osteochondrosis and osteochondral fragments in the fetlock joint is provided. Subsequently, this article delves into the genetic aspects by presenting an overview of significantly associated quantitative trait loci and potential candidate genes. Next, the challenges in both phenotypic and genomic selection against these osteochondral disorders are discussed, with a focus on the difficulties in phenotyping, the establishment of large and representative reference populations, publication bias, lesion-specific heritabilities, and studbook policies. In conclusion, while there is considerable potential to implement preventive measures that can alleviate the economic burden and enhance animal welfare, further research is necessary. This research should utilize precise and standardized phenotype definitions applied across studies with preferably larger populations.
马骨软骨病和蹄骨软骨碎片的遗传因素:范围综述 - 第二部分。
马骨软骨病和跗关节骨软骨碎片与各种环境和遗传风险因素有关。为了评估将这些风险因素与这些骨软骨疾病的发生联系起来的文献范围,同时确定知识差距和挑战,以指导未来的研究,我们进行了一次范围界定综述。本文是该范围界定综述的第二部分,重点讨论遗传因素,第一部分讨论环境因素。为了确定潜在的相关论文,我们使用了在线文献数据库 PubMed 和 Web of Science,并辅以 OMIA 网站(OMIA:000750-9796)上列出的文章。在收集条目、删除重复条目、筛选标题、摘要和全文文件以确定是否符合条件,以及人工检索其余文章的参考文献列表后,本范围综述共确定了 212 项研究。首先,本文简要概述了马跗关节骨软骨病和骨软骨碎片的发病机制。随后,本文深入探讨了遗传学方面的问题,概述了明显相关的数量性状位点和潜在候选基因。接下来,文章讨论了针对这些骨软骨疾病进行表型和基因组选择所面临的挑战,重点是表型的困难、建立大型代表性参考群体、发表偏差、病变特异性遗传力以及种马手册政策。总之,尽管实施预防措施以减轻经济负担和提高动物福利的潜力巨大,但仍有必要开展进一步的研究。这项研究应采用精确和标准化的表型定义,并应用于不同的研究,最好能有更大的群体。
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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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