The Impact of Neonicotinoid Pesticides on Reproductive Health.

IF 3.4 3区医学 Q2 TOXICOLOGY

Toxicological Sciences Pub Date : 2024-10-26 DOI:10.1093/toxsci/kfae138

Jadesola I Oladosu, Jodi A Flaws

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引用次数: 0

Abstract

Neonicotinoids are some of the most widely used insecticides in the world because they broadly target chewing and sucking insects. Neonicotinoids are used in commercial agricultural systems, sold for use in home gardens, and found in veterinary pharmaceuticals in the form of flea and tick preventatives for companion animals. They are also used as crop seed treatments and spread throughout crops as they mature. As a result, humans, wildlife, livestock, and pets are routinely exposed to neonicotinoids through consumption of contaminated food and water as well as through use of some veterinary pharmaceuticals. Although several studies indicate that neonicotinoid exposure causes genotoxicity, neurotoxicity, hepatotoxicity, and immunotoxicity in some non-target species, the impact of neonicotinoid pesticides on the male and female reproductive systems in mammals is largely understudied. This review summarizes current insights on the impact of common neonicotinoid pesticides such as acetamiprid, clothianidin, imidacloprid, and thiacloprid on male and female reproductive health in mammals. The review also summarizes the impacts of exposure to mixtures of neonicotinoids on reproductive endpoints. In addition, this review highlights where gaps in research on neonicotinoid pesticides and reproductive health exist so that future studies can be designed to fill current gaps in knowledge.

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新烟碱类杀虫剂对生殖健康的影响。

新烟碱类杀虫剂是世界上使用最广泛的杀虫剂之一，因为它们广泛针对咀嚼性和吸食性昆虫。新烟碱类杀虫剂被用于商业农业系统，出售给家庭花园使用，并以伴侣动物跳蚤和蜱虫预防剂的形式出现在兽药中。它们还被用作作物种子处理剂，并在作物成熟时扩散到整个作物中。因此，人类、野生动物、牲畜和宠物经常会通过食用受污染的食物和水以及使用某些兽药而接触到新烟碱类物质。尽管一些研究表明，接触新烟碱类杀虫剂会对一些非目标物种造成基因毒性、神经毒性、肝毒性和免疫毒性，但新烟碱类杀虫剂对哺乳动物雌雄生殖系统的影响在很大程度上还未得到充分研究。本综述总结了常见新烟碱类杀虫剂（如啶虫脒、噻虫嗪、吡虫啉和噻虫啉）对哺乳动物雌雄生殖健康影响的最新研究成果。综述还总结了接触新烟碱类混合物对生殖终点的影响。此外，本综述还强调了新烟碱类杀虫剂和生殖健康研究中存在的差距，以便设计未来的研究，填补目前的知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicological Sciences 医学-毒理学

CiteScore

7.70

自引率

7.90%

发文量

118

审稿时长

1.5 months

期刊介绍： The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology. The primary focus of Toxicological Sciences is on original research articles. The journal also provides expert insight via contemporary and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field. The scope of Toxicological Sciences is focused on a broad spectrum of impactful toxicological research that will advance the multidisciplinary field of toxicology ranging from basic research to model development and application, and decision making. Submissions will include diverse technologies and approaches including, but not limited to: bioinformatics and computational biology, biochemistry, exposure science, histopathology, mass spectrometry, molecular biology, population-based sciences, tissue and cell-based systems, and whole-animal studies. Integrative approaches that combine realistic exposure scenarios with impactful analyses that move the field forward are encouraged.