Construction of induced pluripotent stem cell line (CSBZZUi002-A) from the fibroblast cells of a healthy female

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2024-10-20 DOI:10.1016/j.scr.2024.103593

Yue Wu , Xiao-Yan Meng , Hui-Fang Sun , Ying-Jie Zhang , Xiao-Hui Liu , Dian-Dian Wang , Dan-Hua Liu , Sen-Miao Li , Jia-Kang Li , Wen-Xiu Li , Shu-Ang Li , Pei-Pei Liu , Jian-Sheng Kang

引用次数: 0

Abstract

We recruited a healthy 44-year-old female and obtained her skin fibroblasts. Subsequently, the induced pluripotent stem cell line was successfully established using non-integrated reprogramming technology. The cell line had a normal karyotype and has been confirmed to have good pluripotency through the detection of pluripotency markers and detection of teratoma formation. This cell line can serve as an effective control for studying the cellular pathological mechanisms of other specific mutations.

查看原文本刊更多论文

从一名健康女性的成纤维细胞中构建诱导多能干细胞系（CSBZZUi002-A）。

我们招募了一名 44 岁的健康女性，并获得了她的皮肤成纤维细胞。随后，我们利用非整合重编程技术成功建立了诱导多能干细胞系。该细胞系核型正常，通过检测多能性标志物和检测畸胎瘤的形成，证实其具有良好的多能性。该细胞系可作为研究其他特定突变的细胞病理机制的有效对照。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.