A replicate crossover trial on the inter-individual variability of sleep indices in response to acute exercise undertaken by healthy men.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-10-24 DOI:10.1093/sleep/zsae250

Yuting Yang, Alice E Thackray, Tonghui Shen, Tareq F Alotaibi, Turki M Alanazi, Tom Clifford, Iuliana Hartescu, James A King, Matthew J Roberts, Scott A Willis, Lorenzo Lolli, Greg Atkinson, David J Stensel

{"title":"A replicate crossover trial on the inter-individual variability of sleep indices in response to acute exercise undertaken by healthy men.","authors":"Yuting Yang, Alice E Thackray, Tonghui Shen, Tareq F Alotaibi, Turki M Alanazi, Tom Clifford, Iuliana Hartescu, James A King, Matthew J Roberts, Scott A Willis, Lorenzo Lolli, Greg Atkinson, David J Stensel","doi":"10.1093/sleep/zsae250","DOIUrl":null,"url":null,"abstract":"Study objectives: Using the necessary replicate-crossover design, we investigated whether there is inter-individual variability in home-assessed sleep in response to acute exercise.Methods: Eighteen healthy men (mean(SD): 26(6) years) completed two identical control (8-h laboratory rest, 08:45-16:45) and two identical exercise (7-h laboratory rest; 1-h laboratory treadmill run [62(7)% peak oxygen uptake], 15:15-16:15) trials in randomised sequences. Wrist-worn actigraphy (MotionWatch 8) measured home-based sleep (total sleep time, actual wake time, sleep latency, sleep efficiency) two nights before (nights 1-2) and three nights after (nights 3-5) the exercise/control day. Pearson's correlation coefficients quantified the consistency of individual differences between the replicates of control-adjusted exercise responses to explore: (1) immediate (night 3 minus night 2); (2) delayed (night 5 minus night 2); and (3) overall (average post-intervention minus average pre-intervention) exercise-related effects. Within-participant linear mixed models and a random-effects between-participant meta-analysis estimated participant-by-trial response heterogeneity.Results: For all comparisons and sleep outcomes, the between-replicate correlations were non-significant, ranging from trivial-to-moderate (r range = -0.44 to 0.41, P≥0.065). Participant-by-trial interactions were trivial. Individual differences SDs were small, prone to uncertainty around the estimates indicated by wide 95% confidence intervals and did not provide support for true individual response heterogeneity. Meta-analyses of the between-participant, replicate-averaged condition effect revealed that, again, heterogeneity (τ) was negligible for most sleep outcomes.Conclusion: Control-adjusted sleep in response to acute exercise was inconsistent when measured on repeated occasions. Inter-individual differences in sleep in response to exercise were small compared to the natural (trial-to-trial) within-subject variability in sleep outcomes.","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":5.6000,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/sleep/zsae250","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Study objectives: Using the necessary replicate-crossover design, we investigated whether there is inter-individual variability in home-assessed sleep in response to acute exercise.

Methods: Eighteen healthy men (mean(SD): 26(6) years) completed two identical control (8-h laboratory rest, 08:45-16:45) and two identical exercise (7-h laboratory rest; 1-h laboratory treadmill run [62(7)% peak oxygen uptake], 15:15-16:15) trials in randomised sequences. Wrist-worn actigraphy (MotionWatch 8) measured home-based sleep (total sleep time, actual wake time, sleep latency, sleep efficiency) two nights before (nights 1-2) and three nights after (nights 3-5) the exercise/control day. Pearson's correlation coefficients quantified the consistency of individual differences between the replicates of control-adjusted exercise responses to explore: (1) immediate (night 3 minus night 2); (2) delayed (night 5 minus night 2); and (3) overall (average post-intervention minus average pre-intervention) exercise-related effects. Within-participant linear mixed models and a random-effects between-participant meta-analysis estimated participant-by-trial response heterogeneity.

Results: For all comparisons and sleep outcomes, the between-replicate correlations were non-significant, ranging from trivial-to-moderate (r range = -0.44 to 0.41, P≥0.065). Participant-by-trial interactions were trivial. Individual differences SDs were small, prone to uncertainty around the estimates indicated by wide 95% confidence intervals and did not provide support for true individual response heterogeneity. Meta-analyses of the between-participant, replicate-averaged condition effect revealed that, again, heterogeneity (τ) was negligible for most sleep outcomes.

Conclusion: Control-adjusted sleep in response to acute exercise was inconsistent when measured on repeated occasions. Inter-individual differences in sleep in response to exercise were small compared to the natural (trial-to-trial) within-subject variability in sleep outcomes.

查看原文本刊更多论文

一项关于健康男性急性运动时睡眠指数个体间差异性的重复交叉试验。

研究目的采用必要的复制-交叉设计，研究急性运动时家庭评估的睡眠是否存在个体间差异：18名健康男性（平均（标清）：26（6）岁）以随机顺序完成了两项相同的对照试验（8小时实验室休息，08:45-16:45）和两项相同的运动试验（7小时实验室休息；1小时实验室跑步机跑步[62（7）%峰值摄氧量]，15:15-16:15）。腕戴式动仪（MotionWatch 8）在运动/对照日的前两天（1-2日）和后三天（3-5日）测量了在家的睡眠情况（总睡眠时间、实际觉醒时间、睡眠潜伏期、睡眠效率）。皮尔逊相关系数量化了对照组调整后的运动反应重复数据之间的个体差异一致性，以探讨：(1) 即时（第 3 晚减第 2 晚）；(2) 延迟（第 5 晚减第 2 晚）；(3) 整体（干预后平均值减干预前平均值）运动相关效应。参与者内线性混合模型和参与者间随机效应荟萃分析估计了各试验参与者的反应异质性：对于所有比较和睡眠结果，重复间相关性不显著，从微小到中等（r 范围 = -0.44 至 0.41，P≥0.065）。参与者之间的交互作用微不足道。个体差异 SD 值较小，95% 置信区间较宽，容易造成估计值的不确定性，并且不能支持真正的个体反应异质性。对参与者之间的重复平均条件效应进行的元分析表明，对于大多数睡眠结果而言，异质性（τ）同样可以忽略不计：结论：在重复测量急性运动时，对照组调整后的睡眠情况并不一致。与受试者内部睡眠结果的自然（试验到试验）变异性相比，个体间对运动的睡眠反应差异很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.