The effects of purslane (Portulaca oleracea) on C-reactive protein, lipid profile, and glycemic control in patients with type 2 diabetes mellitus: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators Pub Date : 2024-10-23 DOI:10.1016/j.prostaglandins.2024.106917

Guo Donglin , Roya Birjandi , Fatemeh Moghimi Esfandabadi , Amirreza Haedi , Chen Fujiang

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引用次数: 0

Abstract

Although numerous trials have demonstrated the benefits of purslane on patients with type 2 diabetes mellitus (T2DM), the results of some studies reject such effect. We elucidated the influence of purslane on c-reactive protein (CRP), lipid profile, and glycemic control in patients with T2DM. We conducted a systematic search on Web of Sciences, Scopus, the Cochrane Library, PubMed, and Embase, to identify studies published from their inception to February 10, 2024. The random effect model was used to calculate the combined effect, the weighted mean differences (WMDs) and its 95 % confidence interval (CI). Purslane supplementation significantly reduced fasting blood glucose (FBG) levels (WMD: −15.01; 95 % CI: −25.31, −4.71, p= 0.004), total cholesterol (TC) (WMD: −17.75; 95 % CI: −26.06, −9.45; p< 0.001), triglyceride (TG) (WMD: −21.30; 95 % CI: −32.59, −10.00; p< 0.001), low-density lipoprotein cholesterol (LDL-C) (WMD: −6.10; 95 % CI: −9.52, −2.68; p< 0.001), and CRP levels (WMD: −1.44; 95 % CI: −2.25, −0.63; p< 0.001), and increased high-density lipoprotein cholesterol (HDL-C) (WMD: 6.17; 95 % CI: 2.53, 9.80; p< 0.001). Also, purslane did not significant effect on serum levels of insulin, hemoglobin A1C (HbA1c), and homeostatic model Assessment for insulin resistance (HOMA-IR). The results of our study showed that purslane supplementation improved FBG, and lipid profile levels, but did not affect HOMA-IR, insulin, and HbA1c levels. However, high-quality trials are needed to approve our results.

查看原文本刊更多论文

马齿苋对 2 型糖尿病患者 C 反应蛋白、血脂状况和血糖控制的影响：对随机对照试验进行 GRADE 评估的系统综述和荟萃分析。

尽管许多试验证明马齿苋对2型糖尿病（T2DM）患者有益，但一些研究结果却否定了这种作用。我们阐明了马齿苋对 T2DM 患者的 c 反应蛋白（CRP）、血脂状况和血糖控制的影响。我们在 Web of Sciences、Scopus、Cochrane Library、PubMed 和 Embase 上进行了系统检索，以确定从开始到 2024 年 2 月 10 日发表的研究。研究采用随机效应模型计算综合效应、加权平均差（WMD）及其95%置信区间（CI）。补充马齿苋可明显降低空腹血糖 (FBG) 水平（WMD：-15.01；95% CI：-25.31，-4.71，p= 0.004）、总胆固醇 (TC)（WMD：-17.75；95% CI：-26.06，-9.45；p< 0.001）、甘油三酯 (TG)（WMD：-21.30；95% CI：-32.59，-10.00；p< 0.001）、低密度脂蛋白胆固醇（LDL-C）（WMD：-6.10；95% CI：-9.52，-2.68；p< 0.001）和 CRP 水平（WMD：-1.44；95% CI：-2.25，-0.63；p< 0.001），并增加了高密度脂蛋白胆固醇（HDL-C）（WMD：6.17；95% CI：2.53，9.80；p< 0.001）。此外，马齿苋对血清中的胰岛素水平、血红蛋白A1C（HbA1c）和胰岛素抵抗的稳态模型评估（HOMA-IR）没有显著影响。我们的研究结果表明，补充马齿苋可改善血糖和血脂水平，但不会影响 HOMA-IR、胰岛素和 HbA1c 水平。然而，我们的研究结果还需要高质量的试验来验证。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.