Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-10-16 DOI:10.1016/j.prp.2024.155657

Abida , Abdulmalik S.A. Altamimi , Nehmat Ghaboura , Ashok Kumar Balaraman , Pranchal Rajput , Pooja Bansal , Sushama Rawat , Fadiyah Jadid Alanazi , Abeer Nuwayfi Alruwaili , Nouf Afit Aldhafeeri , Haider Ali , Pran Kishore Deb

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引用次数: 0

Abstract

Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.

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lncRNAs 在调控癌症治疗中的治疗潜力

非编码RNA（lncRNA）在各种细胞过程中发挥着关键作用，其中包括一种新型的细胞死亡调控形式，即二硫化血症，其特点是蛋白质二硫键累积和严重的内质网应激。本综述强调了lncRNAs在调控二硫化硫过程中对癌症治疗的潜力，强调了它们对GPX4、SLC7A11和PDIA家族成员等关键通路成分的影响。最近的研究表明，靶向特定的 lncRNA 可使癌细胞对二硫化硫敏感，为癌症治疗提供了一种前景广阔的方法。lncRNAs对二硫化硫的调控涉及多种信号通路，包括氧化应激、ER应激和钙信号转导。这篇综述还讨论了lncRNA调控二硫化硫的分子机制、开发基于lncRNA的疗法所面临的挑战以及这一快速发展的癌症研究领域的未来潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.