In silico analysis and comprehensive review of circular-RNA regulatory roles in breast diseases; a step-toward non-coding RNA precision

IF 2.9 4区 医学 Q2 PATHOLOGY
Nadia M. Hamdy , Mona G. El-Sisi , Sherine M. Ibrahim , Heba ElNokoudy , Ahmad A. Hady , Gamal Eldein Fathy Abd-ellatef , Al-Aliaa M. Sallam , Bassant Mohamed Barakat
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Abstract

In the current comprehensive review, we first highlighted circRNAs, which are key ncRNAs. Next, we discussed the relationships among circRNAs and breast cancer subtypes via in silico databases analysis and extensive literature search. CircRNAs, that sponge miRNA axes or act as silencers of oncogenic mRNAs, have been extensively addressed in the context of this review. During BC pathogenesis, the circRNA/microRNA/messenger RNA (mRNA) axis plays a major role in disease growth, progression, and survival/resistance and could be targeted for improved treatment options. This review also aimed to address oncogenic and tumor suppressor mRNAs, which are regulated by various circRNAs in BC. Moreover, we mentioned the relation of different circRNAs with cancer hallmarks, patient survival together with drug resistance. Additionally, we discussed circRNAs as vaccines and biomarkers in BC. Finally, we studied exosomal circRNAs as a hot interesting area in the research.

Review significance

Via using in silico databases, bioinformatics analysis, and a thorough literature search to first highlight circRNA as a crucial ncRNA and its biogenesis, and then we explored the connection between circRNA and breast illnesses. In the framework of the review, circRNA sponged-miRNAs axis or as silencers to oncogenic mRNAs were extensively discussed. In the pathophysiology of BC, the circular RNA/microRNA/messenger RNA axis is crucial for the propagation of the disease and resistance that may be targeted for more effective treatment options, in order to confront tumor suppressor and oncogenic mRNAs that are presently regulated by circRNAs in BC. For better patient results, we advised further mechanistic research to elucidate additional ncRNA axis that may be targeted for the therapy of BC and for prognosis/ or early diagnosis.
环状 RNA 在乳腺疾病中的调控作用的硅学分析和综合评述;向非编码 RNA 的精确性迈进。
在本综述中,我们首先强调了作为关键 ncRNA 的 circRNAs。接下来,我们通过硅学数据库分析和广泛的文献检索讨论了 circRNAs 与乳腺癌亚型之间的关系。循环RNA是miRNA轴的海绵或致癌mRNA的沉默子,在本综述中已被广泛讨论。在BC发病过程中,circRNA/microRNA/信使RNA(mRNA)轴在疾病的生长、进展和存活/抗性中起着重要作用,可作为靶点改善治疗方案。这篇综述还旨在讨论 BC 中受各种 circRNAs 调控的致癌和抑瘤 mRNA。此外,我们还提到了不同的 circRNA 与癌症特征、患者生存期和耐药性的关系。此外,我们还讨论了作为 BC 疫苗和生物标志物的 circRNAs。最后,我们将外泌体 circRNAs 作为一个热门研究领域进行了研究。综述意义:通过使用硅学数据库、生物信息学分析和全面的文献检索,我们首先强调了circRNA作为一种重要的ncRNA及其生物发生,然后探讨了circRNA与乳腺疾病之间的联系。在综述框架中,我们广泛讨论了circRNA作为miRNA轴或致癌mRNA沉默子的作用。在乳腺癌的病理生理学中,环状RNA/microRNA/信使RNA轴对疾病的传播和抗药性至关重要,可作为更有效治疗方案的靶点,以对抗目前在乳腺癌中受环状RNA调控的抑癌和致癌mRNA。为了给患者带来更好的治疗效果,我们建议进一步开展机理研究,以阐明更多的 ncRNA 轴,这些 ncRNA 轴可能成为治疗 BC 和预后/或早期诊断的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
3.60%
发文量
405
审稿时长
24 days
期刊介绍: Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
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