The Effect of Algae Supplementation on Anthropometric Indices in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
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引用次数: 0
Abstract
Context: Inconsistent results have been reported regarding the effects of different types of algae, such as Spirulina and Chlorella, on anthropometric indices.
Objective: To conduct a meta-analysis to assess the efficacy of algae supplementation on anthropometric indices.
Data sources: A comprehensive systematic search was conducted to find relevant articles published from January 1990 to January 2024.
Data extraction: Randomized controlled trials (RCTs) comparing algae supplementation with a placebo or control group were included. The risk of bias and certainty of the evidence were evaluated using the Cochrane risk-of-bias tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, respectively. The random-effects model was used to find the Weighted mean differences (WMDs) for each outcome.
Data analysis: Of 9079 distinct articles in the initial screening, 61 clinical trials were included in this meta-analysis. Algae supplementation resulted in lower body mass index (WMD, -0.27 kg/m2 (95% CI, -0.42 to -0.13); GRADE rating, low), body weight (WMD: -0.78 kg [-1.18 to -0.38]; GRADE rating, low), waist circumference (WMD, -0.68 cm [-1.27 to -0.10]; GRADE rating, very low), kilograms of body fat (WMD, -0.65 kg [-1.13 to -0.17]; GRADE rating, low), and body fat percentage (WMD, -0.9% [-1.62 to -0.17]; GRADE rating, very low) compared with placebo or controls. Nevertheless, the statistically significant effects of algae supplementation on hip circumference (WMD, -0.20 cm [-0.73 to 0.32]; GRADE rating, moderate), waist to hip ratio (WMD, -0.01 [-0.01 to 0.00]; GRADE rating, moderate), and lean body mass (WMD, -0.30 kg [-0.62 to 0.02]; GRADE rating, moderate) were not observed.
Conclusions: Overall, the findings of this meta-analysis indicate supplementation with algae may exert beneficial effects on anthropometric indices. However, due to between-studies heterogeneity and very low to low levels of GRADE for significant outcomes, the results should be interpreted with caution.
藻类补充剂对成人人体测量指标的影响：经过 GRADE 评估的随机对照试验的系统回顾和元分析》（A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials）。
背景：关于螺旋藻和小球藻等不同类型的藻类对人体测量指数的影响，有报道称结果不一致：进行荟萃分析，评估补充藻类对人体测量指数的功效：数据提取：对1990年1月至2024年1月期间发表的相关文章进行了全面系统的检索：数据提取：纳入了将海藻补充剂与安慰剂或对照组进行比较的随机对照试验（RCT）。分别使用科克伦偏倚风险工具和建议评估、发展和评价分级（GRADE）方法对证据的偏倚风险和确定性进行评估。数据分析采用随机效应模型计算每项结果的加权平均差（WMDs）：在初步筛选的 9079 篇文章中，有 61 项临床试验被纳入本次荟萃分析。补充海藻可降低体重指数（WMD，-0.27 kg/m2 (95% CI, -0.42 to -0.13)；GRADE评分，低）、体重（WMD：-0.78 kg [-1.18 to -0.38]；GRADE评分，低）、腰围（WMD，-0.68 cm [-1.27至-0.10]；GRADE评分，极低）、体脂公斤数（WMD，-0.65公斤[-1.13至-0.17]；GRADE评分，低）和体脂百分比（WMD，-0.9%[-1.62至-0.17]；GRADE评分，极低）与安慰剂或对照组相比。然而，藻类补充剂对臀围（WMD，-0.20厘米[-0.73至0.32]；GRADE评分，中等）、腰臀比（WMD，-0.01[-0.01至0.00]；GRADE评分，中等）和瘦体重（WMD，-0.30千克[-0.62至0.02]；GRADE评分，中等）的影响没有统计学意义：总体而言，这项荟萃分析的结果表明，补充藻类可对人体测量指数产生有益影响。然而，由于研究之间存在异质性，且重要结果的 GRADE 评级很低至很低，因此在解释结果时应谨慎：系统综述注册：PROSPERO 注册号CRD42024522923。
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Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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