First insights into the prevalence, genetic characteristics, and pathogenicity of Bacillus cereus from generations worldwide.

IF 3.7 2区生物学 Q2 MICROBIOLOGY

mSphere Pub Date : 2024-11-21 Epub Date: 2024-10-23 DOI:10.1128/msphere.00702-24

Cuihong Tong, Danyu Xiao, Qi Li, Jing Gou, Shuang Wang, Zhenling Zeng, Wenguang Xiong

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Abstract

Bacillus cereus, a global threat, is one of the major causes of toxin-induced foodborne diseases. However, a comprehensive assessment of the prevalence and characteristics of B. cereus worldwide is still lacking. Here, we applied whole-genome sequence analysis to 191 B. cereus collected in Africa, America, Asia, Europe, and Oceania from the 1900s to 2022, finding that CC142 dominated the global B. cereus clonal complex. The results provided direct evidence that B. cereus could spread through the food chain and intercontinentally. B. cereus from different generations worldwide showed coherence in the antibiotic-resistant gene and virulence and biofilm gene profiles, although with high genomic heterogeneity. The BCI-BCII-vanZF-fosB profiles and virulence and biofilm genes were detected at high rates, and we emphasized that B. cereus would pose a serious challenge to global public health and clinical treatment.IMPORTANCEThis study first emphasized the prevalence, genetic characteristics, and pathogenicity of Bacillus cereus worldwide from the 1900s to 2022 using whole-genome sequence analysis. The CC142 dominated the global Bacillus cereus clonal complex. Moreover, we revealed a close evolutionary relationship between the isolates from different sources. B. cereus isolates from different generations worldwide showed coherence in potential pathogenicity, although with high genomic heterogeneity. The BCI-BCII-vanZF-fosB profiles and virulence and biofilm genes were detected at high rates, and we emphasized that B. cereus would pose a serious challenge to global public health and clinical treatment.

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首次了解全球各代蜡样芽孢杆菌的流行情况、遗传特征和致病性。

蜡样芽孢杆菌是一种全球性威胁，是毒素引发食源性疾病的主要原因之一。然而，目前仍缺乏对蜡样芽孢杆菌在全球的流行情况和特征的全面评估。在此，我们对 1900 年代至 2022 年在非洲、美洲、亚洲、欧洲和大洋洲收集到的 191 株蜡样芽孢杆菌进行了全基因组序列分析，发现 CC142 在全球蜡样芽孢杆菌克隆复合体中占主导地位。研究结果提供了直接证据，证明蜡样芽孢杆菌可通过食物链和洲际传播。全球不同世代的蜡样芽孢杆菌在抗生素耐药基因、毒力和生物膜基因图谱方面表现出一致性，但基因组异质性较高。我们强调，蜡样芽孢杆菌将对全球公共卫生和临床治疗构成严峻挑战。这项研究首次利用全基因组序列分析，强调了从 20 世纪到 2022 年蜡样芽孢杆菌在全球的流行情况、遗传特征和致病性。CC142在全球蜡样芽孢杆菌克隆复合体中占主导地位。此外，我们还发现不同来源的分离株之间存在密切的进化关系。全球不同世代的蜡样芽孢杆菌分离物在潜在致病性方面表现出一致性，但基因组异质性较高。我们强调，蜡样芽孢杆菌将对全球公共卫生和临床治疗构成严峻挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

mSphere Immunology and Microbiology-Microbiology

CiteScore

8.50

自引率

2.10%

发文量

192

审稿时长

11 weeks

期刊介绍： mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.