Oral Pre-Exposure Prophylaxis Innovative Interventions among Adolescent Girls and Young Women in South Africa: A Protocol Paper.

IF 2.3 Q3 BIOCHEMICAL RESEARCH METHODS
Lerato Lucia Olifant, Edith Phalane, Refilwe Nancy Phaswana-Mafuya
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引用次数: 0

Abstract

Although South Africa was the first country to register and roll out oral pre-exposure prophylaxis (PrEP) biomedical human immunodeficiency virus (HIV) prevention intervention in sub-Saharan Africa (SSA), its uptake remains low, particularly among adolescent girls and young women (AGYW). The uptake of PrEP may have worsened during the Coronavirus disease 2019 (COVID-19) pandemic. Some innovative interventions to improve PrEP uptake among AGYW have been implemented. This study aims to evaluate the effectiveness of PrEP innovative interventions implemented during COVID-19 towards reducing the risk of HIV infection among AGYW in South Africa. An exploratory, descriptive design will be conducted to carry out four study objectives. Firstly, to carry out a systematic review of innovative PrEP interventions implemented during COVID-19 in SSA countries. Secondly, to conduct a stakeholder analysis to identify PrEP stakeholders and interview them on their views on the implemented interventions. Thirdly, to assess the implementation outcomes of the innovative interventions using document reviews and Consolidated Framework for Implementation Research. Fourthly, to develop a framework for an improved PrEP service delivery among AGYW. Qualitative data will be captured in ATLAS.ti software (Technical University, Berlin, Germany) version 23 and analysed via thematic analysis. A statistical software package (STATA) version 18 (College Station, TX, USA) will be used to capture quantitative data and analyse them via descriptive analysis. The generated evidence will be used towards the development of framework, guidelines, and policies to strengthen the uptake of, scale-up, and adherence to PrEP among AGYW.

南非少女和年轻妇女口服暴露前预防创新干预措施:协议文件。
尽管南非是撒哈拉以南非洲地区(SSA)第一个注册并推出口服暴露前预防(PrEP)生物医学人类免疫缺陷病毒(HIV)预防干预措施的国家,但其接受率仍然很低,尤其是在少女和年轻女性(AGYW)中。在 2019 年冠状病毒病(COVID-19)大流行期间,PrEP 的吸收情况可能会恶化。目前已实施了一些创新干预措施,以提高少女和年轻女性对 PrEP 的接受率。本研究旨在评估在 COVID-19 期间实施的 PrEP 创新干预措施对降低南非 AGYW 感染 HIV 风险的效果。本研究将采用探索性、描述性设计来实现四个研究目标。首先,对在 COVID-19 期间在撒南非洲国家实施的创新性 PrEP 干预措施进行系统性回顾。第二,对利益相关者进行分析,确定 PrEP 的利益相关者,并就他们对已实施干预措施的看法进行访谈。第三,利用文件审查和实施研究综合框架评估创新干预措施的实施成果。第四,制定一个框架,以改进为非洲青年妇女提供的 PrEP 服务。定性数据将通过 ATLAS.ti 软件(德国柏林工业大学)第 23 版获取,并通过专题分析进行分析。将使用统计软件包 (STATA) 第 18 版(美国德克萨斯州学院站)获取定量数据,并通过描述性分析对其进行分析。生成的证据将用于制定框架、指南和政策,以加强非洲裔青年妇女对 PrEP 的接受、推广和坚持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Methods and Protocols
Methods and Protocols Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
3.60
自引率
0.00%
发文量
85
审稿时长
8 weeks
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