Struggling to Understand the NEC Spectrum-Could the Integration of Metabolomics, Clinical-Laboratory Data, and Other Emerging Technologies Help Diagnosis?
Kosmas Sarafidis, Eleni Agakidou, Angeliki Kontou, Charalampos Agakidis, Josef Neu
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引用次数: 0
Abstract
Necrotizing enterocolitis (NEC) is the most prevalent and potentially fatal intestinal injury mainly affecting premature infants, with significant long-term consequences for those who survive. This review explores the scale of the problem, highlighting advancements in epidemiology, the understanding of pathophysiology, and improvements in the prediction and diagnosis of this complex, multifactorial, and multifaced disease. Additionally, we focus on the potential role of metabolomics in distinguishing NEC from other conditions, which could allow for an earlier and more accurate classification of intestinal injuries in infants. By integrating metabolomic data with other diagnostic approaches, it is hoped to enhance our ability to predict outcomes and tailor treatments, ultimately improving care for affected infants.
坏死性小肠结肠炎（NEC）是主要影响早产儿的最常见且可能致命的肠道损伤，对存活下来的早产儿造成严重的长期后果。本综述探讨了这一问题的严重性，重点介绍了流行病学的进展、对病理生理学的理解以及在预测和诊断这种复杂、多因素和多面性疾病方面的改进。此外，我们还重点探讨了代谢组学在区分 NEC 和其他疾病方面的潜在作用，这有助于更早、更准确地对婴儿肠道损伤进行分类。通过将代谢组学数据与其他诊断方法相结合，我们希望能提高预测结果和定制治疗的能力，最终改善对患病婴儿的护理。
MetabolitesBiochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍：
Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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