Impact of Acupuncture on Human Metabolomic Profiles: A Systematic Review.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-10-11 DOI:10.3390/metabo14100542

Hongjin Li, Hannah Choi, Madelyn C Houser, Changwei Li, Tingting Liu, Shuang Gao, Katy Sullivan, Judith M Schlaeger

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引用次数: 0

Abstract

Background/objectives: Metabolomics provides insights into the biological underpinnings of disease development and treatment. This systematic review investigated the impact of acupuncture on metabolite levels and associated metabolic pathways using a metabolomic approach.

Methods: Five databases (i.e., PubMed, Embase, Scopus, CINAHL, and Cochrane Central) were searched using terms such as "acupuncture" and "metabolites" to retrieve relevant journal articles published through January 2024. Studies utilizing mass spectrometry or nuclear magnetic resonance were included. Risk of bias was evaluated using the Cochrane Risk of Bias tool and the Newcastle-Ottawa scale. Metabolic pathway analysis was conducted using MetaboAnalyst 6.0 to identify common significant pathways affected by acupuncture. Additionally, subgroup pathway enrichment analysis identified metabolites significantly altered in more than two studies.

Results: Among 4019 articles, 22 studies met inclusion criteria, examining changes in metabolomic biomarkers before and after acupuncture for various diseases and symptoms. A total of 226 metabolites showed significant changes, with 14 common metabolites altered in more than two studies (glutamine, androsterone glucuronide, choline, citric acid, decanoylcarnitine, estrone, glutathione, glycine, hypoxanthine, lactic acid, pyruvic acid, serine, proline, and sn-glycero-3-phosphocholine). Common pathways affected by acupuncture were glycine, serine, and threonine metabolism, glutathione metabolism, arginine biosynthesis, and glyoxylate and dicarboxylate metabolism.

Conclusions: This review provides insights of the metabolomic mechanisms underlying acupuncture, highlighting its impact on specific metabolic pathways. Recognizing these changes can enhance acupuncture's effectiveness and support the development of personalized treatments. The findings underscore metabolomics as a valuable tool for understanding and optimizing acupuncture for various diseases and symptoms.

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针灸对人体代谢组学特征的影响：系统综述。

背景/目的：代谢组学为疾病的发生和治疗提供了生物学基础。本系统综述采用代谢组学方法研究针灸对代谢物水平及相关代谢途径的影响：使用 "针灸 "和 "代谢物 "等术语对五个数据库（即 PubMed、Embase、Scopus、CINAHL 和 Cochrane Central）进行了检索，以获取 2024 年 1 月之前发表的相关期刊文章。采用质谱法或核磁共振法的研究也被纳入其中。采用 Cochrane 偏倚风险工具和纽卡斯尔-渥太华量表评估偏倚风险。使用 MetaboAnalyst 6.0 进行代谢通路分析，以确定受针灸影响的常见重要通路。此外，亚组通路富集分析确定了在两项以上研究中发生显著改变的代谢物：在 4019 篇文章中，有 22 项研究符合纳入标准，研究了针灸治疗各种疾病和症状前后代谢组生物标志物的变化。共有 226 种代谢物发生了显著变化，其中 14 种常见代谢物在两项以上的研究中发生了变化（谷氨酰胺、雄酮葡糖醛酸、胆碱、柠檬酸、癸酰肉碱、雌酮、谷胱甘肽、甘氨酸、次黄嘌呤、乳酸、丙酮酸、丝氨酸、脯氨酸和 sn-甘油-3-磷酸胆碱）。针灸影响的常见途径包括甘氨酸、丝氨酸和苏氨酸代谢、谷胱甘肽代谢、精氨酸生物合成以及乙醛酸和二羧酸代谢：本综述深入探讨了针灸的代谢组学机制，强调了针灸对特定代谢途径的影响。认识到这些变化可以提高针灸的疗效，并为开发个性化疗法提供支持。研究结果表明，代谢组学是了解和优化针灸治疗各种疾病和症状的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.