Understanding the chemistry & pharmacology of antibody-drug conjugates in triple-negative breast cancer with special reference to exatecan derivatives.

IF 2.8 4区 医学 Q2 ONCOLOGY
Sanjana Sawant, Gaurav Gopal Naik, Alakh N Sahu, Vijay A Jagtap
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引用次数: 0

Abstract

In the spectrum of breast malignancies, triple-negative breast cancer is the most widely spreading subtype of breast cancer due to a low availability of therapeutic remedies. Recently, antibody-drug conjugates dramatically resolved the landscape for the treatment of triple-negative breast cancer. This review mainly focuses on the chemistry, structure, mechanism of action, and role of antibody-drug conjugates in triple-negative breast cancer. Datopotecan Deruxtecan (Dato-DXd) is a new-generation ADC showing encouraging results for TNBC. In this review, we have also emphasized TROP-2-directed Datopotamab deruxtecan ADCs to treat triple-negative breast cancer, its synthesis, mechanism of action, pharmacokinetics, pharmacodynamics, adverse events, and their ongoing clinical trials.

了解三阴性乳腺癌抗体-药物共轭物的化学和药理学,特别是依沙替康衍生物。
在乳腺恶性肿瘤中,三阴性乳腺癌是传播最广的乳腺癌亚型,原因是治疗方法较少。最近,抗体-药物共轭物的出现极大地改变了三阴性乳腺癌的治疗格局。本综述主要关注抗体-药物共轭物的化学、结构、作用机制以及在三阴性乳腺癌中的作用。Datopotecan Deruxtecan(Dato-DXd)是新一代ADC,对TNBC的治疗效果令人鼓舞。在这篇综述中,我们还强调了TROP-2导向的达托泊他单抗德鲁西坦ADCs治疗三阴性乳腺癌、其合成、作用机制、药代动力学、药效学、不良反应及其正在进行的临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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