Clinical, Quality of Life, and Health Care Utilization Outcomes of Switching the Administration Route of Antipsychotic Medications Among People With Schizophrenia Spectrum Disorder: A Systematic Review and Meta-Analysis.

IF 1.5 4区 医学 Q3 NURSING
Amani Kappi, Tianyi Wang, Bassema Abu Farsakh, Chizimuzo T C Okoli
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引用次数: 0

Abstract

Background: Using long-acting injectable (LAI) antipsychotic medications can improve the outcomes of patients with schizophrenia, such as reducing symptom severity and hospitalization risk. However, the outcomes of switching from oral to LAI antipsychotic medications are unclear.

Aims: The purpose of this review is to provide a summary of the clinical, quality of life, and health care utilization outcomes of switching from oral to LAI antipsychotics among patients with Schizophrenia Spectrum Disorder.

Methods: We thoroughly searched the PubMed, Scopus, PsycInfo, and CINAHL databases. To conduct the meta-analysis, we used the Comprehensive Meta-Analysis Program.

Results: Forty-one articles met our inclusion criteria. After switching to LAIs, symptom severity, the number of rehospitalizations, emergency department visits, and overall health care costs were reduced. Also, social functioning significantly improved. However, no differences were observed in the frequency of outpatient visits. Pharmacy costs were increased between pre- and post-LAI initiation.

Conclusion: Our findings support evidence that changing the route of administration of antipsychotic medications from oral to long-acting intramuscular injections can improve the clinical, quality of life, and health care utilization outcomes in people with schizophrenia. Health care practitioners might consider encouraging LAI use earlier during treatment for schizophrenia for better clinical outcomes and to reduce health care utilization associated with treatment.

精神分裂症谱系障碍患者更换抗精神病药物给药途径的临床、生活质量和医疗保健使用结果:系统回顾与元分析》。
背景:使用长效注射(LAI)抗精神病药物可改善精神分裂症患者的治疗效果,如降低症状严重程度和住院风险。目的:本综述旨在总结精神分裂症谱系障碍患者从口服抗精神病药物转为使用长效注射抗精神病药物的临床、生活质量和医疗保健使用效果:我们全面检索了 PubMed、Scopus、PsycInfo 和 CINAHL 数据库。为了进行荟萃分析,我们使用了综合荟萃分析程序:结果:41 篇文章符合我们的纳入标准。改用LAIs后,症状严重程度、再住院次数、急诊就诊次数和总体医疗费用均有所降低。此外,社会功能也得到了明显改善。然而,在门诊就诊频率方面没有观察到差异。结论:我们的研究结果支持了改变治疗路径的证据:我们的研究结果证明,将抗精神病药物的给药途径从口服改为长效肌肉注射可以改善精神分裂症患者的临床、生活质量和医疗保健利用率。医护人员可以考虑鼓励精神分裂症患者在治疗期间尽早使用长效肌肉注射药物,以获得更好的临床疗效,并减少与治疗相关的医疗费用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
65
期刊介绍: The Journal of the American Psychiatric Nurses Association (JAPNA) is a peer-reviewed bi-monthly journal publishing up-to-date information to promote psychiatric nursing, improve mental health care for culturally diverse individuals, families, groups, and communities, as well as shape health care policy for the delivery of mental health services. JAPNA publishes both clinical and research articles relevant to psychiatric nursing. This journal is a member of the Committee on Publication Ethics (COPE).
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