Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan.

IF 3 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Journal of Personalized Medicine Pub Date : 2024-10-21 DOI:10.3390/jpm14101067

Alma Nurtazina, Ivan Voitsekhovskiy, Bakyt Kanapiyanov, Maxat Toishimanov, Daulet Dautov, Kairat Karibayev, Yerbol Smail, Dana Kozhakhmetova, Altay Dyussupov

{"title":"Associations of Amino Acids with the Risk of Prediabetes: A Case-Control Study from Kazakhstan.","authors":"Alma Nurtazina, Ivan Voitsekhovskiy, Bakyt Kanapiyanov, Maxat Toishimanov, Daulet Dautov, Kairat Karibayev, Yerbol Smail, Dana Kozhakhmetova, Altay Dyussupov","doi":"10.3390/jpm14101067","DOIUrl":null,"url":null,"abstract":"Background: The high global prevalence of prediabetes requires its early identification. Amino acids (AAs) have emerged as potential predictors of prediabetes. This study investigates the association between amino acids and prediabetes in the Kazakh population.Materials and methods: In this case-control study, serum AAs levels were measured using the Trace GC 1310 gas chromatography system coupled with the TSQ 8000 triple quadrupole mass spectrometer (Thermo Scientific, Austin, TX, USA) followed by silylation with the BSTFA + 1% TMCS derivatization method. Biochemical parameters, including total cholesterol, HDL-C, LDL-C, triglycerides, fasting glucose, HbA1c, and Creatinine, were assessed for each participant. Trained professionals conducted anthropometric and physical examinations (which included taking blood pressure and heart rate measurements) and family history collection.Results: A total of 112 Kazakh individuals with prediabetes and 55 without prediabetes, aged 36-65 years, were included in the study. Only Alanine and valine showed a significant association with prediabetes risk among the 13 AAs analyzed. Our findings revealed an inverse relationship between Alanine and Valine and prediabetes in individuals of Kazakh ethnicity.Conclusion: A lower serum level of Alanine and Valine may serve as a predictive biomarker for prediabetes in the Kazakh population.","PeriodicalId":16722,"journal":{"name":"Journal of Personalized Medicine","volume":"14 10","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509736/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Personalized Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/jpm14101067","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The high global prevalence of prediabetes requires its early identification. Amino acids (AAs) have emerged as potential predictors of prediabetes. This study investigates the association between amino acids and prediabetes in the Kazakh population.

Materials and methods: In this case-control study, serum AAs levels were measured using the Trace GC 1310 gas chromatography system coupled with the TSQ 8000 triple quadrupole mass spectrometer (Thermo Scientific, Austin, TX, USA) followed by silylation with the BSTFA + 1% TMCS derivatization method. Biochemical parameters, including total cholesterol, HDL-C, LDL-C, triglycerides, fasting glucose, HbA1c, and Creatinine, were assessed for each participant. Trained professionals conducted anthropometric and physical examinations (which included taking blood pressure and heart rate measurements) and family history collection.

Results: A total of 112 Kazakh individuals with prediabetes and 55 without prediabetes, aged 36-65 years, were included in the study. Only Alanine and valine showed a significant association with prediabetes risk among the 13 AAs analyzed. Our findings revealed an inverse relationship between Alanine and Valine and prediabetes in individuals of Kazakh ethnicity.

Conclusion: A lower serum level of Alanine and Valine may serve as a predictive biomarker for prediabetes in the Kazakh population.

查看原文本刊更多论文

氨基酸与糖尿病前期风险的关系：哈萨克斯坦病例对照研究》。

背景：全球糖尿病前期发病率很高，需要及早发现。氨基酸（AAs）已成为糖尿病前期的潜在预测因子。本研究调查了哈萨克斯坦人群中氨基酸与糖尿病前期之间的关系：在这项病例对照研究中，使用 Trace GC 1310 气相色谱系统和 TSQ 8000 三重四极杆质谱仪（Thermo Scientific, Austin, TX, USA）测量血清 AAs 水平，然后使用 BSTFA + 1% TMCS 衍生方法进行硅烷化。对每位参与者进行了生化参数评估，包括总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、空腹血糖、HbA1c 和肌酐。经过培训的专业人员进行了人体测量和体格检查（包括测量血压和心率），并收集了家族病史：研究共纳入了 112 名患有糖尿病前期的哈萨克人和 55 名无糖尿病前期的哈萨克人，他们的年龄在 36-65 岁之间。在分析的 13 种 AAs 中，只有丙氨酸和缬氨酸与糖尿病前期风险有显著关联。我们的研究结果表明，在哈萨克族人中，丙氨酸和缬氨酸与糖尿病前期之间存在反向关系：结论：较低的血清丙氨酸和缬氨酸水平可作为哈萨克族糖尿病前期的预测生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Personalized Medicine Medicine-Medicine (miscellaneous)

CiteScore

4.10

自引率

0.00%

发文量

1878

审稿时长

11 weeks

期刊介绍： Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.