Determining the Prognostic Value of Complete Blood Count Subgroup Parameters in Staphylococcus aureus Bacteremia.

IF 1.6 Q3 HEALTH CARE SCIENCES & SERVICES
Journal of Patient-Centered Research and Reviews Pub Date : 2024-10-15 eCollection Date: 2024-01-01 DOI:10.17294/2330-0698.2073
Emily L Matthews, Thomas J Dilworth
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引用次数: 0

Abstract

Purpose: Serum cytokine alterations are associated with increased Staphylococcus aureus bacteremia (SAB) mortality. Unfortunately, clinical use of these cytokines is uncommon due to limited availability and high cost. Complete blood count (CBC) with differential reflects the host immune response, and CBC subgroup parameters may have prognostic value in SAB. We sought to determine the association between CBC subgroup parameters on the day of index blood culture and 30-day all-cause mortality in SAB patients.

Methods: We conducted a retrospective study of adult SAB patients with infectious diseases consultation to evaluate the discriminatory capacity of CBC subgroup parameters in predicting SAB mortality. Clinical and microbiological data were collected, including severity of illness and CBC subgroup parameters, on the day of index blood culture. The primary outcome was 30-day all-cause mortality. A multivariable logistic regression model was used to determine the association between patient-level variables and mortality.

Results: A total of 119 patients were included. The overall 30-day all-cause mortality rate was 10.1%. The median neutrophil-to-lymphocyte count ratio (NLCR) among survivors was 13.6 vs 23.2 among non-survivors (p = .007). Median lymphocyte count among survivors was 0.9 x 103 cells/μL vs 0.6 x 103 cells/μL among non-survivors (p = .031). Median platelet count was higher among survivors than non-survivors (239 x 103 cells/μL vs 171 x 103 cells/μL, respectively; p = .018). All other CBC subgroup parameters were similar between the two groups. Known SAB mortality predictors, including age, were also associated with increased mortality. Lower lymphocyte count was independently associated with increased mortality (adjusted odds ratio [aOR] 0.236, 95% confidence interval [CI] 0.064-0.872), as was higher PITT bacteremia score (aOR 2.439, 95% CI 1.565-3.803).

Conclusions: CBC subgroup parameters may have prognostic value in SAB. Additional study is warranted to further ascertain the prognostic value of these readily available laboratory values.

确定金黄色葡萄球菌菌血症全血细胞计数亚组参数的预后价值
目的:血清细胞因子的改变与金黄色葡萄球菌菌血症(SAB)死亡率的增加有关。遗憾的是,由于这些细胞因子供应有限且价格昂贵,临床上很少使用。带有差值的全血细胞计数(CBC)反映了宿主的免疫反应,CBC 亚群参数可能对 SAB 有预后价值。我们试图确定 SAB 患者血液培养指标当天的 CBC 亚群参数与 30 天全因死亡率之间的关系:我们对接受传染病会诊的成年 SAB 患者进行了一项回顾性研究,以评估 CBC 亚组参数在预测 SAB 死亡率方面的鉴别能力。研究收集了患者的临床和微生物学数据,包括疾病严重程度和血培养指标当天的 CBC 亚群参数。主要结果是 30 天的全因死亡率。采用多变量逻辑回归模型确定患者水平变量与死亡率之间的关系:结果:共纳入 119 名患者。30天全因死亡率为10.1%。幸存者的中性粒细胞与淋巴细胞计数比(NLCR)中位数为 13.6,而非幸存者为 23.2(P = .007)。幸存者的淋巴细胞中位数为 0.9 x 103 cells/μL ,而非幸存者为 0.6 x 103 cells/μL (p = .031)。存活者的血小板计数中位数高于非存活者(分别为 239 x 103 cells/μL vs 171 x 103 cells/μL;p = .018)。两组的所有其他 CBC 亚组参数均相似。已知的 SAB 死亡率预测因素(包括年龄)也与死亡率增加有关。淋巴细胞计数越低,死亡率越高(调整赔率[aOR] 0.236,95% 置信区间[CI] 0.064-0.872),PITT菌血症评分越高,死亡率越高(aOR 2.439,95% CI 1.565-3.803):结论:CBC亚组参数可能对SAB有预后价值。结论:CBC亚组参数可能对SAB有预后价值,有必要进行进一步研究,以进一步确定这些现成实验室值的预后价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Patient-Centered Research and Reviews
Journal of Patient-Centered Research and Reviews HEALTH CARE SCIENCES & SERVICES-
自引率
5.90%
发文量
35
审稿时长
20 weeks
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