The Effectiveness of Tramadol in Pain Relief in Chronic Diseases: A Review Based on Clinical Trials.

IF 0.9 Q3 ANESTHESIOLOGY
Kosar Seidmohammadi, Hoda Haghshenas, Sara Moghaddam, Hossein Kargar Jahromi, Hamed Delam
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Abstract

Tramadol is a synthetic opioid with a central effect from the aminocyclohexanol group, which has two main mechanisms of action, including as a weak agonist of opioid receptors and as a norepinephrine and serotonin reuptake inhibitor. The present study presents a review based on clinical trials designed in 2023. In July 2023, six international databases, including Medline/PubMed, ProQuest, Scopus, EMBASE, Google Scholar, and ISI (Web of Science), were searched and 58 articles were included in the study. The results of most studies showed that tramadol can be used as an analgesic drug, although in some studies it was shown that tramadol is not therapeutically superior in reducing pain compared to other treatments. Also, complications related to this treatment have been reported in some studies. Physicians should consider these factors to prevent drug toxicity, poor pain relief, use disorder in patients, and unpredictable complications. It should be noted that there is not enough evidence to support the long-term effectiveness of tramadol, but this argument also extends to nonopioid and other types of opioid analgesics, and the lack of long-term trials is due to regulatory and ethical issues. Although opioids can cause addiction when used for a long time, tramadol has a reasonable safety profile. According to the patient's condition and the clinical judgment of the medical professional, tramadol can be prescribed for patients, but the consequences of its use must be considered and a personalized treatment algorithm should be selected if the benefits outweigh the risks of the drug.

曲马多缓解慢性病疼痛的疗效:基于临床试验的综述
曲马多是一种由氨基环己醇基团合成的具有中枢效应的阿片类药物,其主要作用机制有两种,包括作为阿片受体的弱激动剂以及去甲肾上腺素和五羟色胺再摄取抑制剂。本研究基于 2023 年设计的临床试验进行综述。2023 年 7 月,研究人员检索了 Medline/PubMed、ProQuest、Scopus、EMBASE、Google Scholar 和 ISI(Web of Science)等六个国际数据库,共收录了 58 篇文章。大多数研究结果表明,曲马多可作为镇痛药物使用,但也有一些研究结果表明,与其他治疗方法相比,曲马多在减轻疼痛方面并不具有治疗优势。此外,一些研究还报告了与该疗法相关的并发症。医生应考虑这些因素,以防止药物毒性、疼痛缓解效果不佳、患者用药紊乱以及不可预测的并发症。需要注意的是,目前还没有足够的证据支持曲马多的长期有效性,但这一论点也适用于非阿片类和其他类型的阿片类镇痛药,缺乏长期试验是由于监管和伦理问题。虽然长期使用阿片类药物会导致成瘾,但曲马多的安全性是合理的。根据患者的病情和专业医务人员的临床判断,可以为患者开具曲马多处方,但必须考虑到使用该药物的后果,并在利大于弊的情况下选择个性化的治疗算法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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